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Principal Investigator
Ya-Ping Zhang   China Ph.D. Genetics Zoology  
Title Deputy president, Chinese Academy of Sciences; Principle Investigator
Phone +86 871 65130513
Fax +86 871 65130513
E-mail zhangyp@mail.kiz.ac.cn
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Zip Code 650223
 
   Education and Appointments:

Deputy president, Chinese Academy of Sciences. 

Distinguished Professor, Yunnan University. 

Vice director of Chinese Society of Genetics; vice director of Chinese Society of Zoology. 

Member of Biodiversity Committee of Chinese Academy of Sciences. 

Vice director of Chinese Anthropology and Ethnology Committee. 

Vice director of the 14 th Bioscience and Medicine Academic Divisions Executive Committee of Chinese Academy of Sciences. 

Member of IUCN/SSC Primate and Lagomorpha Specialist Group. 

Vice Editor-in-chief of Genome Biology and Evolution, Animal Genetics. 

Editorial Board of Human Molecular Genetics, Scientific Reports. 

Curriculum vitae 

    2012− Deputy president, Chinese Academy of Sciences

    2007  Academician of Third World Academy of Sciences (TWAS)

    20052012  Director, Kunming Institute of Zoology, the Chinese Academy of Sciences

    2003 Academician of the Chinese Academy of Sciences, Distinguished Professor, Yunnan University

    19962006  Director, Laboratory of Livestock and poultry Molecular biology of Yunnan Province

    19962005  Vice Director, Kunming Institute of Zoology, the Chinese Academy of Sciences

    19952000  Professor & Director, Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences.

    19921995  San Diego Zoo, Center for Reproduction of Endangered Species (CRES) Postdoctoral fellow

    19911992  Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China Assistant Professor

    19861991  Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China Ph.D. Genetics Zoology

    19821986  Fudan University, Shanghai B.S. Biochemistry

  Professional Services
Distinguished Professor, Yunnan University. Vice director of Chinese Society of Genetics; Vice director of Chinese Society of Zoology. Member of Biodiversity Committee of Chinese Academy of Sciences. Vice director of Chinese Anthropology and Ethnology Committee. Vice director of the 14 th Bioscience and Medicine Academic Divisions Executive Committee of Chinese Academy of Sciences. Member of IUCN/SSC Primate and Lagomorpha Specialist Group. Editorial Board of Animal Genetics, Acta Genet. Sinica, Zoological Research, Hereditas, Cell Research, Chinese Biodiversity, Progress in Nature Science, Acta Zoologica Sinica, Acta Zootaxonomica Sinica.
   Research Interests:

Molecular evolution and genome biodiversity. Investigations involve five correlated areas: genome diversity and adapt ive evolution; origin of domestic animals and artificial selection; human & animls genetics and evolution. 

  • Genome diversity and adaptive evolution 

Integrated with habitat and behavioral data, we investigate genomic variation, how (and why) the variations are selected , and the evolutionary forces underlying adaptation. Explore the fate of duplicate genes, how novel gene functions, new gene pathways, and gene networks evolved. 

  • Origin of domestic animals and artificial selection 

Our studies into the origin and genetic diversity of economically important domestic animals identify their unrecorded history. Genomic comparisons elucidate the genetic bases of domestication, and discover changes in genes or genomic elements that contribute to domestication. 

  • Human & animals genetics and evolution 

We use DNA sequence data to reconstruct the pre-history of modern humans and the evolutionary relationships of species, and to investigate the population genetic structure of selected important species. In addition, we probe the genetic causes underlying specific human traits and major diseases, explore changes in morphology, ecology, physiology, and behavior, as well as the mechanisms of speciation and macroevolutionary biogeography.

  Supported Projects:

1. Major Project from National Natural Science Foundation of China “Studies of evolution and cryptic diversity of standard genes of DNA Barcoding in animals” 2011.1201.12 

2. Project from National Natural Science Foundation of China “Origin of genetic novelties in genomes and their significance in the evolution and adaptation of animals” 2014.1−2016.12 

3. National 973 Project “Genetic and genomic evolution mechanisms of important domesticates under artificial selection” 2013.1-2017.8 

- Subproject “Genetic and Genomic basic of phenotype evolution in dogs” 

- Subproject “Evolution mechanism of artificial selection in pigs, cattle and chickens” 

4. Project from Ministry of Agriculture “Identification and cloning of important functional genes in domesticated animals based on artificial selection analyses” 

5.  The Strategic Priority Research Program of the Chinese Academy of Sciences “Innovative system of Molecular Module designed breeding” 2013.8−2018.7 

— Subproject “Development and improvement of molecular breeding base of swine in southeastern China.”

  Public Services:
  Honors:

Biodiversity Leadership Awards, Bay and Paul Foundations, USA, 2002 

Pace-setter for Young Scientists & Technologies of China, the Government of China, 1994 

Natural Science Prizes of Yunnan Province, First Grade, 1996(Molecular evolution of genus Macaca) 

The 3rd Prizes for Young Scientists of China, the Government of China, 1996 

Natural Science Prizes of China, Third Grade, 1997(Cellular and Molecular Evolution of endemic and rare animals in China) 

Natural Science Prizes of Yunnan Province, First Grade, 2001(Study on the biology of Yunnan Snub-nosed monkey) 

May 4th Youth Medal of China, 2004 

Prizes for Innovation of Life Sciences(Conference of Global Chinese biological scientist), 2004 

Ho Leung Ho Lee Prize for Science and Technology, Ho Leung Ho Lee Foundation, 2004 

Prizes of Outstanding Contribution for Science & Technologies of Yunnan Province, 2005 

Natural Science Prizes of Yunnan Province, First Grade, 2005(Mitochondrial Genomic Diversity and History of Human Population in East Asia) 

Natural Science Prizes of China, Second Grade, 2006(Mitochondrial Genomic Diversity and History of Human Population in East Asia) 

ChangJiang River Scholar Accomplishment Award, First Grade, 2006 

The 2th Achievement Award for Life Sciences of Tan Jiazhen, 2009 

Natural Science Prizes of Yunnan Province, First Grade, 2010(Molecular Phylogeny of Eutheria (Placental Mammals) 

Natural Science Prizes of Yunnan Province, Top Grade, 2013(Genome Diversity and Evolution of Asian) 

Natural Science Prizes of Yunnan Province, First Grade, 2013(Molcular mechanism of adaptive evolution of animals)

  Selected Publications:

(* corresponding author)

1.  He L, Wu WJ, Yang JK, Cheng H, Zuo XB, Lai W, Gao TW, Ma CL, Luo N, Huang JQ, Lu FY, Liu YQ, Huang YJ, Lu QJ, Zhang HL, Wang L, Wang WZ, Wang MM, Xiao SX, Sun Q, Li CY, Bai YP, Li H, Zhou ZC, Zhou FS, hen G, Liang B, Qi J, Yang XY, Yang T, Zheng X, Sun LD, Zhang XJ, and Zhang YP*. Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne. Nature Communications, 2014, 5. 

2.  Li Y, Wu DD, Boyko AR, Wang GD, Wu SF, Irwin DM, Zhang YP*. 2014. Population variation revealed high-altitude adaptation of Tibetan Mastiffs. Molecular Biology and Evolution,31(5):1200-1205. 

3.  Ge RL, Cai QL, Shen YY, Murphy RW, Wang J, Zhang YP*, Wang J*. Draft genome sequence of the Tibetan antelope. Nature Communications, 2013, 4. 

4.  Li Y, vonHoldt BM, Reynolds A, Boyko AR, Wayne RK, Wu DD*, Zhang YP*. Artificial selection on brain-expressed genes during the domestication of dog. Molecular Biology and Evolution 2013,30(8):1867-76. 

5.  Wang GD, Zhai WW, Yang HC, Fan RX, Cao X, Zhong L, Wang L, Liu F, Gao Y, Lv XM, Irwin DM, Savolainen P, Wu CI*, Zhang YP*. The genomics of selection in dogs and the parallel evolution between dogs and humans. Nature Communications, 2013,4:1860. 

6.  Li JT, Li Y, Klaus S, Rao DQ, Hillis DM, Zhang YP*. Diversification of rhacophorid frogs provides evidence for accelerated faunal exchange between India and Eurasia during the Oligocene. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(9): 3441-3446. 

7.  Murphy RW, Crawford AJ, Bauer AM, Che J, Donnellan SC, Fritz U, Haddad CFB, Nagy ZT, Poyarkov NA, Vences M, Wang WZ, Zhang YP*. Cold code: the global initiative to DNA barcode amphibians and nonavian reptiles. Molecular Ecology Resources, 2013, 13(2): 161-167. 

8.  Yan F, Zhou WW, Zhao HT, Yuan ZY, Wang YY, Jiang K, Jin JQ, Murphy RW, Che J*, Zhang YP*. Geological events play a larger role than Pleistocene climatic fluctuations in the genetic structure of the montane stream-dwelling frog Quasipaa boulengeri (Anura: Dicroglossidae) in southern China. Molecular Ecology, 2013, 22: 1120-1133. 

9.  Che J, Chen HM, Yang JX, Jin JQ, Jiang K, Yuan ZY, Murphy RW, Zhang YP*.Universal COI primers for DNA barcoding amphibians. Molecular Ecology Resources, 2012, 12(2): 247-258. 

10. Chen R, Irwin DM, Zhang YP*. Differences in selection drive olfactory receptor genes in different directions in dogs and wolf. Molecular Biology and Evolution, 2012, 29(11): 3475-3484. 

11. Ji LD, Qiu YQ, Xu J, Irwin DM, Tam SC, Tang NL, Zhang YP*. Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among Eurasian human populations. Molecular Biology and Evolution, 2012, 29(11): 3359-3370. 

12. Jin W, Wu DD, Zhang X, Irwin DM, Zhang YP*. Positive selection on the gene RNASEL: correlation between patterns of evolution and function. Molecular Biology and Evolution, 2012, 29(10): 3161-3168. 

13. Shen YY, Liang L, Li GS, Murphy RW, Zhang YP*. Parallel evolution of auditory genes for echolocation in bats and toothed whales. PloS Genetics,  2012, 8(6): e1002788. 

14. Zhou WW, Wen Y, Fu JZ, Xu YB, Jin JQ, Ding L, Min MS, Che J, Zhang YP*. Speciation in the Ranachensinensis species complex and its relationship to the uplift of the Qinghai-Tibetan Plateau. Molecular Ecology, 2012, 21(4): 960-973. 

15. Gao JJ, Pan XR, Hu J, Ma L, Wu JM, Shao YL, Barton SA, Woodruff RC, Zhang YP*, Fu YX. Highly variable recessive lethal or nearly lethal mutation rates during germ-line development of male Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America,  2011, 108(38): 15914-15919. 

16. Kong QP, Sun C, Wang HW, Zhao MA, Wang WZ, Zhong L, Hao XD, Pan H, Wang SY, Cheng YT, Zhu CL, Wu SF, Liu LN, Jin JQ, Yao YG, Zhang YP*. Large-scale mtDNA screening reveals a surprising matrilineal complexity in East Asia and its implications to the peopling of the region. Molecular Biology and Evolution, 2011, 28(1): 513-522. 

17. Sun YB, Shen YY, Irwin DM, Zhang YP*. Evaluating the roles of energetic functional constraints on teleost mitochondrial-encoded protein evolution. Molecular Biology and Evolution, 2011, 28(1): 39-44. 

18. Wu DD, Irwin DM, Zhang YP*. De novo origin of human protein-coding genes. PloS Genetics, 2011, 7(11): e1002379. 

19. Yu L, Luan PT, Jin W, Ryder OA, Chemnick LG, Davis HA, Zhang YP*. Phylogenetic utility of nuclear introns in interfamilial relationships of Caniformia (Order Carnivora). Systematic Biology2011, 60(2):175-187. 

20. Bawa KS, Koh LP, Lee TM, Liu JG, Ramakrishnan PS, Yu DW, Zhang YP, Raven PH. China, India, and the environment. Science, 2010, 327(5972): 1457-1459. 

21. Che J, Zhou WW, Hu JS, Yan F, Papenfuss TJ, Wake DB, Zhang YP*. Spiny frogs (Paini) illuminate the history of the Himalayan region and Southeast Asia. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(31): 13765-13770. 

22. Peng MS, Quang HH, Dang KP, Trieu AV, Wang HW, Yao YG, Kong QP, Zhang YP*. Tracing the Austronesian footprint in Mainland Southeast Asia: a perspective from mitochondrial DNA. Molecular Biology and Evolution, 2010, 27(10):2417-2430. 

23. Shen YY, Liang L, Zhu ZH, Zhou WP, Irwin DM, Zhang YP*. Adaptive evolution of energy metabolism genes and the origin of flight in bats. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(19): 8666-8671. 

24.  Wu DD, Zhang YP*. Positive selection drives population differentiation in the skeletal genes in modern humans. Human Molecular Genetics, 2010, 19(12): 2341-2346. 

25.     Yu L, Jin W, Wang JX, Zhang X, Chen MM, Zhu ZH, Lee H, Lee M, Zhang YP*. Characterization of TRPC2, an essential genetic component of VNS chemoreception, provides insights into the evolution of pheromonal olfaction in secondary-adapted marine mammals. Molecular Biology and Evolution, 2010, 27(7): 1467-1477. 

26.     Yu L, Wang XY, Jin W, Luan PT, Ting N, Zhang YP*: Adaptive evolution of digestive RNASE1 genes in leaf-eating monkeys revisited: new insights from ten additional colobines. Molecular Biology and Evolution, 2010, 27(1): 121-131. 

27.     Zhang DR, Chen MY, Murphy RW, Che J, Pang JF, Hu JS, Luo J, Wu SJ, Ye H, Zhang YP*. Genealogy and palaeodrainage basins in Yunnan Province: phylogeography of the Yunnan spiny frog, Nanorana yunnanensis (Dicroglossidae). Molecular Ecology, 2010, 19(16): 3406-3420. 

28.     Zhong L, Zhang YP, Fu WP, Dai LM, Sun C, Wang YQ. The Relationship between GSTP1 I105V polymorphism and COPD: a reappraisal. American Journal of Respiratory and Critical Care Medicine, 2010, 181(7): 763-765 

29. Pang JF, Kluetsch C, Zou XJ, Zhang AB, Luo LY, Angleby H, Ardalan A, Ekstrom C, Skollermo A, Lundeberg J, Matsumura S, Leitner T, Zhang YP*, Savolainen P: mtDNA data indicate a single origin for dogs South of Yangtze River, less than 16,300 years ago, from numerous wolves. Molecular Biology and Evolution, 2009, 26(12): 2849-2864. 

30. Shen YY, Shi P, Sun YB, Zhang YP*: Relaxation of selective constraints on avian mitochondrial DNA following the degeneration of flight ability. Genome Research, 2009, 19(10): 1760-1765. 

31. Wu DD, Wang GD, Irwin DM, Zhang YP*. A profound role for the expansion of trypsin-like serine protease family in the evolution of hematophagy in mosquito. Molecular Biology and Evolution, 2009, 26(10): 2333-2341. 

32. Zhao M, Kong QP, Wang HW, Peng MS, Xie XD, Wang WZ, Jiayang, Duan JG, Cai MC, Zhao SN, Cidanpingcuo, Tu YQ, Wu SF, Yao Y, Bandelt HJ, Zhang YP*. Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(50): 21230-21235. 

  Research Team:

Researchers

Dr. Robert W. Murphy, Visiting Professor

Dr. David Irwin, Visiting Professor

Dr. Yun Gao, Associate Professor; gaoy@mail.kiz.ac.cn

Dr. Dong-Dong Wu, Associate Professor

Dr. Min-Sheng Peng, Associate Professor

Dr. Guo-Dong Wang, Associate Professor, wanggd1983@gmail.com

Dr. Hai-Bing Xie, Assistant Professor, resian@263.net

Dr. Rui Chen, Assistant Professor

Ms. Jing He, Assistant Professor, he_jing2006@hotmail.com

Mr. Yun-Fei Ma, Resarch Assistant

 

Technicians

Ms. Shi-Fang Wu; Ms. Chun-Ling Zhu; Mr. Peng-Biao Yang; Mr. Wei-Feng Hao; Ms Yu-Ping Yao

 

Postdoctoral Fellows

Dr. Jia-Tang Li2009; Dr. Chuan-Jiang Zhou, 2011; Dr. Yan Li, 2012; Dr. Lin-Dan Ji, 2012; Dr. Gang Ni, 2013

 

Graduate Students

SY Wang; HC Yang; F Yan; HQ Liu; L Liang; ZY Yuan; J Liu; ZY Zhou; X Cao; MS Wang; F Liu; Y Yang; XM Han; Y Shao; HB Xu; D Xu; LQ Ye; L Zeng;

TT Yin; CP Huang; NN Shi; YX Huo; YM Wang; MD Lu; Y Yao; Nguyen Ngoc Sang; Adeola Adeniyi Charles

 
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