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Principal Investigator
Bin Liang   Ph.D  
Phone +86 871 65181927
Address Kunming Institute of Zoology, the Chinese Academy of Sciences. 32 Jiao chang Dong lu, Kunming, Yunnan, 650223, P.R.China
Zip Code 650223
   Education and Appointments:

Education Background

2001.09—2004.07   Ph.D    Fudan University
1999.09—2001.07   M.S    Yunnan University 
1990.09—1994.07   B.S     Yunnan University 

Academic Experiences

2006.10?2010.07   Washington State University, Postdoctoral fellow, Assistant Research Professor 
2006.07?2006.10   Albert Einstein College of Medicine of Yeshiva University. Postdoctoral fellow 
2004.12?2006.07   University of California, Irvine. Postdoctoral fellow 
2004.03?2004.11   Yunnan Academy of Agricultural Sciences.
1994.07?1999.08   Yunnan Academy of Agricultural Sciences.

2010.07-?current     Kunming Institute of Zoology, Chinese Academy of Science. Professor
  Professional Services
   Research Interests:

1, The regulations of fat storage and distributions 

Animals often store extra energy as fat in adipose tissues for later utilization. Metabolic syndromes induced by overloaded and ectopic fat storage, such as obesity, type 2 diabetes, fatty liver, cardiovascular diseases, etc.. are currently epidemic worldwide. We use C. elegans, rodents, and mammalian cell lines via genetic, molecular, and biochemical methods to investigate the regulation mechanisms of fat storage and distributions. 

Stearoyl-CoA desaturase (SCD) is one of key enzymes in fat biosynthesis and energy homeostasis. The disruption of SCD in both mice and C. elegans significantly decreases their fat storage and body weight. However, the over-expression of SCD leads to the excessive fat storage associated with obesity, type 2 diabetes, fatty liver, etc. Currently, we have screened several genes regulating the expression of SCD, and now are exploring the roles of these SCD regulators and SCD play in fat storage. 

2, The tree shrew and monkey models of human fatty liver and type 2 diabetes 

Nonhuman primates and their relatives are popular animal models of human diseases in biomedical research. Tree shrews (Tupaia belangeri), which mainly habitat in tropical and subtropical regions like Yunnan Province, have been used in biomedical research for many years. The large populations of  tree shrews and monkeys that Kunming Institute of Zoology breeds enables us to establish the tree shrew and monkey models of human fatty liver and type 2 diabetes, which will benefit pathogenetic studies and drug evaluations.

  Supported Projects:

1. The Innovative Program of the Chinese Academy of Sciences (KSCX2-EW-R-12) (2011.012013.12,¥1,000,000) 

2. The Innovative Program of the Chinese Academy of Sciences (KSCX2-EW-J-23) (2011.012013.12,¥270,000) 

3. The National Natural Science Foundation of China (31171134) (2012.012015.12,¥600,000) 

4. The National Natural Science Foundation of China (31160216) (2012.012015.12,¥500,000)  

5. The National Natural Science Foundation of China (U1202223) (2013.012016.12,¥2,000,000)

  Public Services:
  Selected Publications:

1. Wu X*, Zou X*, Chang Q, Zhang Y, Li Y, Zhang L, Huang J, Liang B#. 2013. The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes. BioMed Research International. doi:10.1155/2013/856521. (#Corresponding author) (*Equal contribution) 

2. Shi X*, Li J*, Zou X, Greggain J, Rodkaer SV, Faergeman NJ, Liang B#, Watts JL#. 2013.The regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase. J Lipid Res. Vol 54, 2504–2514 . (#Corresponding author) (*Equal contribution) 

3. Yuru Zhang, Xiaoju zou, Yihong Ding, Haizhen Wang, Xiaoyun Wu, Bin Liang#. 2013. Comparative Genomics and Functional Study of Lipid Metabolic Genes in Caenorhabditis elegans. BMC Genomics.14:164. doi:10.1186/1471-2164-14-164. (#Corresponding author) 

4. XU Lin, ZHANG Yun, LIANG Bin, Lü Long-Bao, CHEN Ce-Shi, CHEN Yong-Bin, ZHOU Ju-Min, YAO Yong-Gang. 2013. The tree shrew under the spot light: emerging models of human diseases. Zoological Research. Apr. 34(2): 59-69. (in Chinese) 

5. Xiao-Yun WU, Yun-Hai LI, Qing CHANG, Lin-Qiang ZHANG, Sha-Sha LIAO, Bin LIANG#. 2013. Streptozotocin induction of type 2 diabetes in tree shrew. Zoological Research..Apr. 34(2): 89-96. (# Corresponding author) (in Chinese) 

6.X. Wu*, Q. Chang*, Y. Zhang*, X. Zou, L. Chen, L. Zhang, L.Lvand B. Liang#. 2013. Relationships between body weight, fasting blood glucose, sex and age in tree shrews (Tupaia belangeri chinensis). J Anim Physiol Anim Nutr. Jan 22. doi: 10.1111/jpn.12036.. (#Corresponding author) (*Equal contribution) 

7.Yu Fan, Zhi-Yong Huang, Chang-Chang Cao, Ce-Shi Chen, Yuan-Xin Chen, Ding-Ding Fan, Jing He, Hao-Long Hou, Li Hu, Xin-Tian Hu, Xuan-Ting Jiang, Ren Lai,Yong-Shan Lang, Bin Liang, Sheng-Guang Liao, Dan Mu, Yuan-Ye Ma, Yu-Yu Niu, Xiao-Qing Sun, Jin-Quan Xia, Jin Xiao, Zhi-Qiang Xiong, Lin Xu, Lan Yang, Yun Zhang, Wei Zhao, Xu-Dong Zhao, Yong-Tang Zheng, Ju-Min Zhou, Ya-Bing Zhu, Guo-Jie Zhang, Jun Wang & Yong-Gang Yao. 2013. Genome of the Chinese Tree Shrew. Nature Communications.Volume:4, DOI:doi:10.1038/ncomms2416. 

8.Rong-Xia Li, Wei Xu, Zhen Wang, Bin Liang, Jia-Rui Wu, Rong Zeng. 2012. Proteomic characteristics of liver and muscle of Chinese tree shrew (Tupaia belangeri chinensis). Protein & Cell. 3(9): 691-700. 

9.Zou Xiao-Jü, Ding Yi-Hong, Liang Bin#. 2012. The mechanisms of weight-cutting effect in Pu-erh tea. Zoological Research. Aug. 33(4): 421-426. (# Corresponding author) (in Chinese) 

10.Gholamali Jafari*, Yusu Xie*, Andrey Kullyev, Bin Liang, and Ji Ying Sze. 2011.Regulation of extra-synaptic 5-HT by SERT function in 5-HT-absorbing neurons underscores adaptation behavior in C. elegans. J. Neurosci., 31(24):8948-8957. 

11.Liang Bin#Wu Xiao-yun. 2011. Progress on nonhuman primate models of diabetes mellitus. Zoological ResearchFeb. 32(1): 91-96 (# Corresponding author) (in Chinese) 

12.Bin Liang, Kim Ferguson, Lisa Kadyk, and Jennifer L. Watts. 2010 .The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS One, 5(3) e9869. 

13.Kyleann K. Brooks, Bin Liang, Jennifer L. Watts. 2009.The influence of bacterial diet on fat storage in C. elegans. PLoS One4(10) e7545. 

14.Bin Liang, Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze. 2006. Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Cell Metabolism, Dec;4(6):429-440. (Preview on Cell Metabolism, 2006 Dec; 4(6):415-417.)

  Research Team:

Laboratory Staff 

Dr. Xiao-Yun Wu, Research Associate 

Dr. Yu-Ru Zhang, Research Associate 

Ms. Qing Chang, Secretary, changqing 

Mr. Yun-Hai Li, Research Assistant     

Graduate Students 

Cang-Sang XieHai-Zhen WangJing-Jing ZhangZhi-Guo  ZhangYi-Hong DingLin-Qiang Zhang
Sha-Sha  Liao, Xue  JiangJie-Yu WuZhi-Qing DiaoWei Zhang 

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