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Principal Investigator
Ce-Shi Chen   Ph.D.  
Title Professor
Phone +86 871 65181944
Fax +86 871 65181945
E-mail chenc@mail.kiz.ac.cn
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
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   Education and Appointments:

2011 – present  Professor, Kunming Institute of Zoology, Chinese Academy of Sciences  

2009 –2011  Associate Professor (Tenure Track), the Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY, USA  

2006 –2009  Assistant Professor (Tenure Track), the Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY, USA  

2004 –2006  Instructor, Winship Cancer Institute, Emory University, Atlanta, GA, USA  

2002–2004  Postdoctoral fellow, Winship Cancer Institute, Emory University, Atlanta, GA, USA 

1999 –2002  Research Associate in Department of Pathology, University of Virginia, Charlottesville, VA. USA  

1994 1999  Ph.D. in Pharmacology, Shanghai Research Center of Biotechnology & Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.   

1990 1994  B.Sc. in Microbiology, Department of Biology, Nankai University, Tianjin, China.

  Professional Services
   Research Interests:

Breast cancer is most common lethal disease. To develop more effective strategies for cancer prevention and control, early detection, diagnosis, and treatment, we must obtain a more complete understanding of the causes of cancer and of the biological mechanisms of cancer initiation and progression. Many genetic, molecular, and cellular events influence the cancer process. Protein ubiquitination and transcription factors regulate an enormous range of biological processes; including transcription, cell cycle, apoptosis, and migration. Consistently, defects in these systems have already been directly implicated with human cancer. Our current projects are to study (1) E3 ubiquitin ligases and deubiquitinases in cancer development, (2) the KLF5 transcription factor in breast cancer stem cells, (3) the tree shrew models for human breast cancers 4anti-cancer drug development. In summary, our research interests are the cancer genetics and biology of human cancers. In long term, we hope to identify more potential diagnostic biomarkers and drug targets for cancer targeted therapy

  Supported Projects:

Current:  

1. National Natural Science Foundation of China, HECTD3 regulates breast cancer apoptosis through ubiquitinating caspase8 (81120108019), ¥2,400,000, Jan 2012 - Dec, 2016  

2. National Key Basic Research Program of China (2013CB910900), ¥2,500,000, Jan 2013 –Dec 2017  

3. National Natural Science Foundation of China, Tumor biology (81325016),¥3, 200,000, Jan 2014 - Dec, 2017  

Completed:  

1. American Cancer Society (ACS), Molecular Genetics and Oncogenes (MGO) “The Role of the WWP1 E3 Ubiquitin Ligase in Human Breast Cancer”, Jul 2008 - Jun, 2012 (PI: Ceshi Chen).  

2. Department of Defense (DOD), PCRP, The Oncogenic Role of WWP1 E3 Ubiquitin Ligase in Prostate Cancer Development. May 2007-Apr 2011 (PI: Ceshi Chen).  

3. Susan G. Komen Breast Cancer Grant, The role of KLF5 transcription factor degradation in breast cancer. May 2005-Apr 2009. (PI: Ceshi Chen).  

4. Department of Defense (DOD), BCRP, BC075738, WWP1 targets ErbB4 for ubiquitin-mediated degradation in breast cancer. Sep 2008-Aug 2009 (PI: Ceshi Chen).  

5. National Natural Science Foundation of China, HECTD3: a novel E3 ligase promoting breast cancer cell survival, 81072162, ¥400,000, Jan 2011 - Dec, 2013  

6. National Natural Science Foundation of China, KLF5 transcription factor mediates the function of YAP oncoprotein in breast cancer (U1132605), ¥2,000,000, Jan 2012 - Dec, 2015

  Public Services:
  Honors:

1.  1990-1994: Scholarship from NanKai University, three times, China  

2.  1997: Award for Excellent Graduate Student, Chinese Academy of Sciences, China  

3.  1998: Prize of Excellent Paper from Shanghai Association of Biotechnology, China  

4.  1998: Di’ao Scholarship from Chinese Academy of Sciences, China  

5.  2002: Scholar-in-Training Award from American Association for Cancer Research, USA  

6.  2004: American Foundation for Urologic Disease, Research scholar, USA  

7.  2005: Georgia Cancer Coalition Cancer Research Award, USA  

8.  2008: American Cancer Society, Research Scholar Award, USA  

9.  2009: New Teacher Award, Sosa Academy of Medicine, Albany Medical Center, USA  

10. 2010: High-Profile Scientist  in Yunnan Province  

11. 2011: Outstanding oversea scientist of Chinese Academy of Sciences  

12. 2013: Outstanding Young Scientist of National Science Foundation of China  

13. 2016 Young Scientific Innovation Leader of Chinese Ministry of Science and Technology

  Selected Publications:

(corresponding authors)

 

1.   Rong Liu, Xu Zhi, Zhongmei Zhou, Hailin Zhang, Runxiang Yang, Tianning Zou and Ceshi Chen, Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1, Scientific Reports, (2018) 8:1138 | DOI:10.1038/s41598-018-19489-6.

2.   Huichun Liang, Ji Xiao, Zhongmei Zhou, Hailin Zhang, Zongcheng Li, Jian Sun, Fubing Li, Rong Liu*, and Ceshi Chen*, Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF-1α/VEGFA axis in breast cancer angiogenesis, Oncogene, 2018, doi:10.1038/s41388-017-0089-8

3.    Zekun Chen#, Qiuju Wu#, Ye Ding, Wenhui Zhou, Rong Liu, Haiying Chen, Jia Zhou*, Jing Feng*, Ceshi Chen*, YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway, Theranostics 2017; 7(8):2339-2349.

4.   Peiguo Shi, Wenjing Liu, Tala, Haixia Wang, Fubing Li, Hailin Zhang, Yingying Wu, Yanjie Kong, Zhongmei Zhou, Chunyan Wang, Wenlin Chen, Rong Liu, Ceshi Chen*, Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation, Cell Discovery, 2017, 3(17010), doi:10.1038/celldisc.2017.10

5.   Ming Shao?, Guang-Zhe Ge?, Wen-Jing Liu?, Ji Xiao, Hou-Jun Xia, Yu Fan, Feng Zhao, Bao-Li He, Ceshi Chen*, Characterization and Phylogenetic Analysis of Krüppel-like Transcription Factor (KLF) Gene Family in Tree Shrews (Tupaia belangeri chinensis). Oncotarget, 2017, 8 (10), 16325-16339.

6.   Jing Wu, Ye Ding, Chuan-Hui zhi Chen, Zhongmei Zhou, Chunyong Ding, Haiying Chen, Jia Zhou*, Ceshi Chen*, A New Oridonin Analog Suppresses Triple-Negative Breast Cancer Cells and Tumor Growth via the Induction of Death Receptor 5. Cancer Letters, 2016, 380(2),393-402

7.   Kong Y?, Li F?, Nian Y?, Zhou Z, Yang R*, Qiu MH*, Chen C*. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway. Theranostics 2016; 6(6):875-886.

8.   Rong Liu*, Peiguo Shi, Zhi Nie, Huichun Liang, Zhongmei Zhou, Wenlin Chen, Haijun Chen, Chao Dong, Runxiang Yang, Suling Liu, Ceshi Chen*Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 ExpressionTheranostics 2016; 6(4): 533-544

9.   Guang-Zhe Ge?, Hou-Jun Xia?, Bao-Li He, Hai-Lin Zhang, Wen-Jing Liu, Ming Shao, Chun-Yan Wang, Ji Xiao, Fei Ge, Fu-Bing Li, Yi Li, Ceshi Chen*, Generation and Characterization of a Breast Carcinoma Tree Shrew Model by PyMT Overexpression in Mammary Epithelial Cells, Int J Cancer, 20161383),642-651

10.   Junying Qin, Zhongmei Zhou, Wenlin Chen, Chunyan Wang, Hailin Zhang, Guangzhe Ge, Ming Shao, Dingyun You, Zhixiang Fan, Houjun Xia, Rong Liu, Ceshi Chen* BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5, Nature Communications, 2015, 6: 8471, doi:10.1038/ncomms9471

11.   Lin Jia, Zhongmei Zhou, Huichun Liang, Jing Wu, Peiguo Shi, Fubing Li, Zehua Wang, Chunyan Wang, Wenlin Chen, Hailin Zhang, Yang Wang, Rong Liu, Jing Feng*, Ceshi Chen* KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2, Oncogene, 2015 Jul 20. doi: 10.1038/onc.2015.263.

12.   Chunyan Wang?,Zhi Nie?, Zhongmei Zhou, Hailin Zhang, Rong Liu, Jing Wu, Junying Qin, Yun Ma, Liang Chen, Shumo Li, Wenlin Chen, Fubing Li, Peiguo Shi, Yingying Wu, Jian Shen, Ceshi Chen*, The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1, Oncotarget, 2015

13.   Fei Ge?, Wenlin Chen?, Junying Qin?,Zhongmei Zhou, Rong Liu, Linlin Liu,Jing Tan, Tianning Zou,Hongyuan Li, Guosheng Ren*, Ceshi Chen*, Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation bydeubiquitinatingKrüppel-like factor 5 (KLF5), Oncotarget, 2015

14.   Hou-Jun Xia, Bao-Li He, Chun-Yan Wang, Hai-Lin Zhang, Guang-Zhe Ge,  Yuan-Xu Zhang, Long-Bao Lv, Jian-Lin Jiao, Ceshi Chen*, PTEN/PIK3CA genes are frequently mutated in spontaneous and MPA-accelerated DMBA induced mammary tumours of tree shrews, Eur J Cancer, 2014, 50(18):3230-3242

15.   Yi Li#, Yanjie Kong#, Zhongmei Zhou, Hui Chen, Zehua Wang, Yi-Ching Hsieh, Dong Zhao, Xu Zhi, Jian Huang, Jing Zhang, Hongmin Li, Ceshi Chen* The HECTD3 E3 Ubiquitin Ligase Facilitates Cancer Cell Survival by Promoting K63-linked Polyubiquitination of Caspase-8, Cell Death and Disease, 2013, 4, e935 

16.   Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C*. Kruppel-Like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer. J Biol Chem. 2013 288(37):26731-40 

17.   Zehua Wang, Zhi Nie, Wenlin Chen, Zhongmei Zhou, Qinghua Kong, Arun Seth, Rong Liu*, Ceshi Chen*RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21 for Ubiquitin-mediated DegradationNeoplasia, 2013 15(9):1028-35 

18.   Yi Li, Xi Chen, Zehua Wang, Dong Zhao, Hui Chen, Wenlin Chen, Zhongmei Zhou, Junran Zhang, Jing Zhang, Hongmin Li, Ceshi Chen*The HECTD3 E3 Ubiquitin Ligase Suppresses Cisplatin-induced Apoptosis via Stabilizing MALT1Neoplasia, 2013, 15(1)39-48 

19.   Xu Zhi, Dong Zhao, Zehua Wang, Zhongmei Zhou, Chunyan Wang, Wenlin Chen, Rong Liu*, Ceshi Chen*, E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation, Cancer Res. 2013;73(1):385-94 

20.   Xu Zhi, Dong Zhao, Zhongmei Zhou, Rong Liu, Ceshi Chen*, YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor, Am J Pathology, 2012, 180(6): 2452-61 

21.   Dong Zhao, Xu Zhi, Zhongmei Zhou, Ceshi Chen*, TAZ antagonizes theWWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis, Carcinogenesis, 2012, 33(1): 59-67  

22.   Rong Liu, Zhongmei Zhou, Dong ZhaoCeshi Chen*, The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and de-differentiation, Mol. Endocrinology, 2011, 25(7): 1137-1144 (Cover)  

23.   Rong Liu, Zhongmei Zhou, Jian Huang, Ceshi Chen*, PMEPA1 promotes androgen receptor negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21Cip1 signaling pathway, Journal of Pathology, 2011, 223(5): 683-94 

24.   Dong Zhao, Hanqiu Zheng, Zhongmei Zhou, Ceshi Chen*, The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation, Cancer Research, 2010, 70: 4728-38  

25.   Hanqiu Zheng, Zhongmei Zhou, Leena Chaudhury, Jin-Tang Dong, Ceshi Chen*, Krüpple-like factor 5 (KLF5) promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor-binding protein 1 (FGF-BP) in breast cancer, Oncogene, 2009; 28: 3702-13. 

26. Rong Liu, Hanqiu Zheng, Zhongmei Zhou, Jin-Tang Dong, Ceshi Chen*, KLF5 promotes breast cell survival partially through FGF-BP-pERK-mediated MKP-1 protein phosphorylation and stabilization, J Biol Chem., 2009 19; 284: 16791-8 

27. Yi Li, Zhongmei Zhou, Maurizio Alimandi, Ceshi Chen*, WW domain containing E3 ubiquitin protein ligase 1 targets the full length ErbB4 for ubiquitin-mediated degradation in breast cancer, Oncogene, 2009 20; 28: 2948-58 Yi Li, Zhongmei Zhou, Ceshi Chen*, WW domain containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis, Cell Death and Differentiation, 2008, 15: 1941-51 

  Research Team:

Laboratory  Staff: 

Dr. Rong Liu, Associate Professor, liurong@mail.kiz.ac.cn 

Ms. Zhong-Mei Zhou , Technician , zhouzm@mail.kiz.ac.cn 

Ms. Hai-Lin Zhang, Technician , zhanghl0327@mail.kiz.ac.cn 

Graduate Students 

Lin JiaChun-Yan WangJun-Ying QinJing WuPei-Guo ShiYan-Jie KongXi Chen 

Fu-Bing LiGuang-Zhe GeSi-Yuan LiMing Shao 

 
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