Search: 
Home | Contact | Sitemap | 中文 | CAS
  
  About Research Education Partnerships People Resources  
Location: Home > People > Staff
   
LeaderShip
CAS Members
Principal Investigator
Division of Medical Genetics & Evolutionary Medicine
Yong-Gang Yao   Ph.D.  
Title Director of Kunming Institute of Zoology
Phone +86 871 65180085;68125440
Fax +86 871 65180085
E-mail yaoyg@mail.kiz.ac.cn
Address Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology, Chinese Academy of Sciences Kunming, Yunnan, China 650223
Zip Code 650223
 
   Education and Appointments:

EDUCATION, TRAINING AND RESEARCH EXPERIENCE

2014.07 – Current, Director of Kunming Institute of Zoology, Chinese Academy of Sciences
2012.04 – 2014.07, Acting Director of Kunming Institute of Zoology, Chinese Academy of Sciences
2007.12 – Current, Principal Investigator; Kunming Institute of Zoology, Chinese Academy of Sciences
2004.10 – 2008.01, Visiting Fellow; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
2003.02 – 2004.09, Postdoctoral Fellow; Wilmer Eye Institute, Johns Hopkins University School of Medicine
1997.09 – 2003.01, Ph. D.; Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
2001.05 – 2001.08, Visiting Scholar; Fachbereich Mathematik, Universität Hamburg, Hamburg, Germany
1997.09 – 1998.07, Graduate School of the Chinese Academy of Sciences, Beijing
1993.09 – 1997.07, B.S.; Department of Biology, Anhui Normal University

  Professional Services
 
   Research Interests:

Our laboratory focuses on understanding the genetic basis and molecular mechanisms of human disorders and aging. We are striving for EAF (E = Evolutionary analysis; A = Association study; F = Functional assay), Easy And Fun.

Current research has three major concentrations:

(1) Genetic basis and molecular mechanism for neurologic disorders and immunologic diseases;
(2) Mitochondrial dysfunction in neurodegenerative diseases and drug addiction;
(3) Biology of Chinese tree shrews.

In addition, students in Yao lab are encouraged to develop their own interdisciplinary projects.

  Supported Projects:
 
  Public Services:
  Honors:

2012 Zhuliyuehua Excellent Teacher. 

2010 Excellent Expert with Outstanding Contribution of Yunnan Province, Second Class (with no First Class Laureate in this year). 

2009 State Class Persons of National New Century Talents Award. 

2006  State Natural Science Award of China (second class). Awardees: Ya-Ping Zhang, Yong-Gang Yao, Qing-Peng Kong, Yuan-Chun Ding, Chang Sun; project title: Mitochondrial genome diversity and population history of East Asian.  

2005  The top 100 Ph.D. thesis of China. Thesis title: Demographic History of the Chinese Ethnic Groups: a Mitochondrial DNA Perspective. 

2004  Excellent Ph.D. thesis of the Graduate School of the Chinese Academy of Sciences. Thesis title: Demographic History of the Chinese Ethnic Groups: a Mitochondrial DNA Perspective. 

2004  Award for Science and Technology Advancement of Yunnan Province (third class). Awardees: Lu-Ming Dai, Ya-Ping Zhang, Xin Lu, Yong-Gang Yao, Min Yang, Jian-Qing Zhang, Li-Zhou Fang; project title: ß2-adrenoceptor polymorphisms and asthma exacerbations. 

2003  Award for Science and Technology Advancement of Yunnan Province (third class). Awardees: Xue-Ping Li, Ya-Ping Zhang, Xiao-Yong Man, Yong-Gang Yao, Chang-Zhi Mao, Huai-Rong Luo, Jing-Fen Zheng; project title: Association of complement C4 null genes and C2 gene genotypes with systemic lupus erythematosus in southwest Han Chinese. 

2002  Special President Scholarship for postgraduate students of the Chinese Academy of Sciences. 

2001  Short-term fellowship from the German Deutscher Akademischer Austauschdienst (DAAD).  

2000  Di-Ao Scholarship and President Scholarship of the Chinese Academy of Sciences. 

1998  Dongshi Eastern Fellowship, Graduate School of the Chinese Academy of Sciences, Beijing.

  Selected Publications:

  (* corresponding author) 

1. Yu D, Xu L, Peng L, Chen S-Y, Liu Y-P, Yao Y-G*. 2014. Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens. Gene, 545: 226-32. 

2. Fan Y, Yu D, Yao Y-G*. 2014. Positively selected genes of the Chinese tree shrew (Tupaia belangeri chinensis) locomotion system. Zoological Research, 35: 240−248. 

3. Lu J, Zou Y, Xu L, Yang R-X, Fan Y, Zhang W, Yu D*, Yao Y-G. 2014. IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma. Medical Science Monitor, 20: 247-254. 

4. Bi R, Zhao L, Zhang C, Lu W, Feng J-Q, Wang Y, Ni J, Zhang J, Li G-D, Hu Q-X, Wang D, Yao Y-G*, Li T*. 2014. No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals. Neurobiology of Aging, 35: 444.e5-444.e9. 

5. Bandelt H-J, Brandstatter A-K, Richards MB, Yao Y-G, Logan I. 2014. The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies. Journal of Human Genetics, 59: 66-77. 

6. Shao X-L, He S-Y, Zhuang X-Y, Fan Y, Li Y-H, Yao Y-G. 2014. mRNA expression and DNA methylation in three key genes involved in caste differentiation in female honeybees (Apis mellifera). Zoological Research, 35: 92-98. 

7. Hu S-P, Du J-P, Li D-R, Yao Y-G. 2014. Mitochondrial DNA Haplogroup Confers Genetic Susceptibility to Nasopharyngeal Carcinoma in Chaoshanese from Guangdong, China. PLoS One, 9(1): e87795. 

8. Li X, Zhang W, Zhang C, Gong W, Tang J, Yi Z, Wang D, Lu W, Fang Y, Chen X, Yao Y-G*. 2014. No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese. Neuroscience Letters, 566: 210-215. 

9. Peng M-S, He J-D, Fan L, Liu J, Adeola AC, Wu S-F, Murphy RW, Yao Y-G, Zhang Y-P. 2013. Retrieving Y chromosomal haplogroup trees using GWAS data. European Journal of Human Genetics, doi:10.1038/ejhg.2013.272. 

10. Liu Y-P, Lai R, Yao Y-G, Zhang Z-K, Pu E-T, Cai X-H, Luo X-D. 2013. Induced furoeudesmanes: A defense mechanism against stress in Laggera pterodonta, a chinese herbal plant. Organic Letters, 15: 4940-4943. 

11. Yao Y-G*, Kajigaya S, Samsel L, McCoy JP Jr, Torelli G, Young NS. 2013. Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 751-752: 36-41. 

12. Zheng M, Bi R, Li W, Landeck L, Chen J-Q, Lao L-M, Cai S-Q, Yao Y-G, Man X-Y. 2013. Generalized pure cutaneous Rosai-Dorfman disease: a link between inflammation and cancer not associated with mitochondrial DNA and SLC29A3 gene mutation? Discovery Medicine, 16: 193-200. 

13. Sun J, Zhong H, Chen S-Y, Yao Y-G, Liu Y-P. 2013. Association between MT-CO3 haplotypes and high-altitude adaptation in Tibetan chicken. Gene, 529: 131–137. 

14. Zhang A-M, Wang H, Sun P, Hu Q-X, He Y, Yao Y-G*. 2013. Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families. Molecular Vision, 19: 1631-1638. 

15. Xiao M-S, Chang L, Li W-L, Du Y-S, Pan Y, Zhang D-F, Wen Y, Luo J, Li X-Y*, Yao Y-G*. 2013. Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from Southwest China. PLoS One, 8(7): e67577 

16. Liu X-H, Yao Y-G*. 2013. Characterization of 12 polymorphic microsatellite markers in the Chinese tree shrew (Tupaia belangeri chinensis). Zoological Research, 32: E62-E68. 

17. Feng Y-M, Jia Y-F, Su L-Y, Wang D, Lv L, Xu L*, Yao Y-G*. 2013. Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. Autophagy, (in press) 

18. Fan L, Yao Y-G*. 2013. An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination. Mitochondrion, 13:360-363 (doi: 10.1016/j.mito.2013.04.011). 

19. Zhuang X-Y, Yao Y-G*. 2013. Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-druplex ligands. FEBS Letter, 587:1656-62 (doi: 10.1016/j.febslet.2013.04.010). 

20. Zhang D-F, Huang X-Q, Wang D, Li Y-Y, Yao Y-G*. 2013. Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China. Human Genetics, 132:629-640 (doi 10.1007/s00439-013-1273-8). 

21. Tu Z, Zhuang X, Yao Y-G, Zhang R. 2013. BRG1 is required for formation of senescence-associated heterochromatin foci (SAHF) induced by oncogenic RAS or BRCA1 loss. Molecular and Cellular Biology, 33:1819-1829 (doi: 10.1128/MCB.01744-12). 

22. Fan Y, Huang Z-Y, Cao C-C, Chen C-S, Chen Y-X, Fan D-D, He J, Hou H-L, Hu L, Hu X-T, Jiang X-T, Lai R, Lang Y-S, Liang B, Liao S-G, Mu D, Ma Y-Y, Niu Y-Y, Sun X-Q, Xia J-Q, Xiao J, Xiong Z-Q, Xu L, Yang L, Zhang Y, Zhao W, Zhao X-D, Zheng Y-T, Zhou J-M, Zhu Y-B, Zhang G-J*, Wang J*, Yao Y-G*. 2013. Genome of the Chinese tree shrew. Nature Communications, 4:1426 (doi: 10.1038/ncomms2416). 

23. Yao Y-G*, Kajigaya S, Feng X, Samsel L, McCoy JP, Jr, Torelli G, Young NS. 2013. Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background. Stem Cell Research, 10:361-370 (http://dx.doi.org/10.1016/j.scr.2013.01.006). 

24. Li Y-Y, Chen W-Y, Li X, Li H-B, Li H-Q, Wang L, He L, Yang X-P, Wang X-C, Huang Y-L, Yao Y-G. 2013. Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan province of China. BMC Infectious Diseases,13(1):46 (doi: 10.1186/1471-2334-13-46). 

25. Li D-X, Zhuang X-Y, Zhang Y-P, Guo H, Wang Z, Zhang Q, Feng Y-M, Yao Y-G*. 2013. Effects of tai chi on the protracted abstinence syndrome: a time trial analysis. The American Journal of Chinese Medicine, 41:43-57 (doi: 10.1142/S0192415X13500043). 

26. Ma L, Zhang W, Tang J, Tan L, Yao Y-G*, Chen X. 2013. No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese. Psychiatric Genetics, 23:29-32 (doi: 10.1097/YPG.0b013e32835862c5). 

27. Miao Y-W, Peng M-S, Wu G-S, Ouyang Y-N, Yang Z-Y, Yu N, Liang J-P, Pianchou G, Beja-Pereira A, Mitra B, Palanichamy M-G, Baig M, Chaudhuri TK, Shen Y-Y, Kong Q-P, Murphy RW, Yao Y-G, Zhang Y-P. 2013. Chicken domestication: an updated perspective based on mitochondrial genomes. Heredity,110: 277-282 (doi: 10.1038/hdy.2012.83). 

28. Ma L, Tang J, Wang D, Zhang W, Liu W, Wang D, Liu X-H, Gong W, Yao Y-G*, Chen X*. 2013. Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China. Molecular Psychiatry, 18:638-639 (doi: 10.1038/mp.2012.63). 

29. Chen S-Y, Yao Y-G, Liu Y-P. 2012. Species identification of ten common farm animals based on mitochondrial 12S rRNA gene polymorphisms. Animal Biotechnology, 23:213-220 (doi: 10.1080/10495398.2012.696568). 

30. Bi R, Zhang A-M, Jia X, Zhang Q, Yao Y-G*. 2012. Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G>A and Leber hereditary optic neuropathy. Molecular Vision,18:3087-3094. 

31. Guo H, Zhuang X-Y, Zhang A-M, Zhang W, Yuan Y, Guo L, Yu D-D, Liu J, Yang D-K, Yao Y-G*. 2012. Presence of mutation m.14484T>C in a Chinese family with maternally inherited essential hypertension but no expression of LHON. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,1822:1535-1543 (doi: 10.1016/j.bbadis.2012.06.010). 

32. Li Y, Zhang D-F, Zhang S-W, Zeng Y*, Yao Y-G*. 2012. Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease. International Journal of Hematology, 96:229-233 (doi: 10.1007/s12185-012-1104-z) 

33. Zhang A-M, Jia X, Guo X, Zhang Q*, Yao Y-G*. 2012. Mitochondrial DNA mutation m.10680G>A is associated with Leber hereditary optic neuropathy in Chinese patients. Journal of Translational Medicine,10(1):43 (doi: 10.1186/1479-5876-10-43). 

34. Wang D, Feng JQ, Li Y-Y, Zhang D-F, Li X-A, Li Q-W, Yao Y-G*. 2012. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China. Human Genetics, 131:1251-1260 (doi: 10.1007/s00439-012-1153-7). 

35. He J-D, Peng M-S, Quang H-H, Dang K-P, Trieu AV, Wu S-F, Jin J-Q, Murphy RW, Yao Y-G, Zhang Y-P. 2012. Patrilineal perspective on the Austronesian diffusion in Mainland Southeast Asia. PLoS ONE, 7(5): e36437. 

36. Wang D, Su L-Y, Zhang A-M, Li Y-Y, Li X-A, Chen L-L, Long H, Yao Y-G*. 2012. Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in han chinese from southwest China. PLoS ONE,7(6): e38848. 

37. Liu J, Wang L-D, Sun Y-B, Li E-M, Xu L-Y, Zhang Y-P, Yao Y-G, Kong Q-P. 2012. Deciphering the signature of selective constraints on cancerous mitochondrial genome. Molecular Biology and Evolution, 29: 1255-1261. 

38. Xu L, Chen S-Y, Nie W-H, Jiang X-L, Yao Y-G*. 2012. Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: implication for using tree shrew as an alternative experimental animal to primates in biomedical research. Journal of Genetics and Genomics, 39: 131-137. 

39. Zhang Z-R, Zhu Q, Yao Y-G, Jiang X-S, Du R-H, Liu Y-P. 2012. Characterization of the expression profile of calpain-3 (CAPN3) gene in chicken. Molecular Biology Reports, 39: 3517-3521.  

40. Zhang A-M, Jia X, Bi R, Salas A, Li S, Xiao X, Wang P, Guo X, Kong Q-P, Zhang Q*, Yao Y-G*. 2011. Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients. PLoS ONE, 6(11): e27750 (doi: 10.1371/journal.pone.0027750). 

41. Zhang A-M, Bandelt H-J, Jia X, Zhang W, Li S, Yu D, Wang D, Zhuang X-Y, Zhang Q*, Yao Y-G*. 2011. Is mitochondrial tRNAphe variant m.593T>C a synergistically pathogenic mutation in Chinese LHON families with m.11778G>A? PLoS ONE, 6(10): e26511 (doi: 10.1371/journal.pone.0026511). 

42. Lu F-Y, Xu L, Yin X-G, Wan P, Zhang X-D, Chen W-W, Ding S-P, Yao Y-G*. 2011. Identification of mutation c.632G>A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier’s disease. International Journal of Dermatology, 50: 1366-1370 (doi: 10.1111/j.1365-4632.2011.05129.x). 

43. Kong Q-P, Sun C, Wang H-W, Zhao M, Wang W-Z, Zhong L, Hao X-D, Pan H, Wang S-Y, Cheng Y-T, Zhu C-L, Wu S-F, Liu L-N, Jin J-Q, Yao Y-G, Zhang Y-P. 2011. Large-scale mtDNA screening reveals a surprising matrilineal complexity in East Asia and its implications to the peopling of the region. Molecular Biology and Evolution, 28: 513-522. 

44. Xiao M-S, Zhang D-F, Zeng Y, Cheng Y-F, Yao Y-G*. 2011. Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients. Annals of Hematology, 90: 1137-1144. 

45. Bi R, Zhang A-M, Yao Y-G. 2011. Leber's Hereditary Optic Neuropathy. Ophthalmology, 118:1489-1489.e1 (doi: 10.1016/j.ophtha.2011.04.007; comments). 

46. Liu F-L, Yao Y-G, Li H, Zheng Y-T. 2011. Human rights, ethics, and the protection of intravenous drug users are much improved in China. JAIDS Journal of Acquired Immune Deficiency Syndromes, 57:e31-e32. 

47. Chen S-Y, Xu L, Lü L-B, Yao Y-G*. 2011. Genetic diversity and matrilineal structure in Chinese tree shrews inhabiting Kunming, China. Zoological Research, 32:17-23. 

48. Bi R, Li W-L, Chen M-Q, Zhu Z, Yao Y-G*. 2011. Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 709-710:15-20. 

49. Fan L, Yao Y-G*. 2011. MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations. Mitochondrion, 11: 351-356. 

50. Peng M-S, Palanichamy MG, Yao Y-G, Mitra B, Cheng YT, Zhao M, Liu J, Wang H-W, Pan H, Wang W-Z, Zhang A-M, Zhang W, Wang D, Zou Y, Yang Y, Chaudhuri TK, Kong Q-P, Zhang Y-P. 2011. Inland post-glacial dispersal in East Asia revealed by mitochondrial haplogroup M9a'b. BMC Biology, 9: 2 (doi: 10.1186/1741-7007-9-2). 

51. Wang Y, Zhu Q, Zhao XL, Yao Y-G, Liu Y-P. 2011. Age-related expression profile of the SLC27A1 gene in chicken tissues. Molecular Biology Reports, 38: 5139-5145. 

52. Li Y-Y, Li X-A, He L, Qang D, Chen W-Y, Chen L, Lu J-B, Yao Y-G. 2011. Trends in new leprosy case detection over 57 years (1952-2008) in Yuxi, Yunnan Province of Southwest China. Leprosy Review, 82:6-16. 

53. Zhang W, Chen X*, Gong W, Tang J, Tan L, Guo H, Yao Y-G*. 2010. Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese. Behavioral and Brain Functions, 6: 75 (doi: 10.1186/1744-9081-6-75).

54. Yu D, Jia X, Zhang A-M, Li S, Zou Y, Zhang Q*, Yao Y-G*. 2010. Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C. PLoS ONE, 5(10): e13426. 

55. Chen S-Y, Liu Y-P, Yao Y-G*. 2010. Species authentication of commercial beef jerky based on PCR-RFLP analysis of the mitochondrial 12S rRNA gene. Journal of Genetics and Genomics, 37: 763-769 

56. Zou Y, Zeng Y, Zhang D-F, Zou S-H, Cheng Y-F*, Yao Y-G*. 2010. IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders. Biochemical and Biophysical Research Communications, 402: 378-383. 

57. Bi R, Zhang A-M, Zhang W, Kong Q-P, Wu B-L, Yang X-H, Wang D, Zou Y, Zhang Y-P, Yao Y-G*. 2010. The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells. Human Mutation, 31: 538-543. 

58. Zou Y, Jia X, Zhang A-M, Wang W-Z, Li S, Guo X, Kong Q-P, Zhang Q*, Yao Y-G*. 2010. The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations. Biochemical and Biophysical Research Communications, 399: 179-185. 

59. Zhang A-M, Jia X, Zhang Q*, Yao Y-G*. 2010. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A. Human Genetics, 128: 465-468. 

60. Bi R, Zhang A-M, Yu D, Chen D, Yao Y-G*. 2010. Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR. Clinica Chimica Acta, 411: 1671-1674. 

61. Peng M-S, Quang H-H, Dang K-P, Trieu A-V, Wang H-W, Yao Y-G, Kong Q-P, Zhang Y-P. 2010. Tracing the Austronesian footprint in mainland Southeast Asia: a perspective from mitochondrial DNA. Molecular Biology and Evolution, 27: 2417-2430. 

62. Yu D, Jia X, Zhang A-M, Guo X, Zhang Y-P, Zhang Q*, Yao Y-G*. 2010. Molecular characterization of six Chinese families with m.3460G>A and Leber hereditary optic neuropathy. Neurogenetics, 11: 349-356. 

63. Wang Y, Zhu Q, Zhao XL, Yao Y-G*, Liu Y-P*. 2010. Association of FATP1 gene polymorphisms with chicken carcass traits in Chinese meat-type quality chicken populations. Molecular Biology Reports, 37: 3683-3690. 

64. Kong Q-P, Bandelt H-J, Zhao M, Zhang Y-P, Yao Y-G. 2010. Reply to van Oven: Suggestions and caveats for naming mtDNA haplogroup. Proceedings of the National Academy of Sciences of the United States of America, 107: E40-E41 (doi: 10.1073/pnas.1000977107; comment). 

65. Wang Q, Wang P, Li S, Xiao X, Jia X, Guo X, Kong Q-P, Yao Y-G, Zhang Q. 2010. Mitochondrial DNA haplogroup distribution in Chaoshanese with and without myopia. Molecular Vision, 16: 303-309. 

66. Zhou B, Chen S-Y, Zhu Q, Yao Y-G, Liu Y-P. 2010. Matrilineal components and genetic relationship of Silkies from China and Japan. Journal of Poultry Science, 47: 22-27. 

67. Yao Y-G, Salas A, Logan I, Bandelt H-J. 2009. mtDNA data-mining in GenBank needs surveying. American Journal of Human Genetics, 85: 929-933. 

68. Zhao M, Kong Q-P, Wang H-W, Peng M-S, Xie X-D, Wang W-Z, Jiayang, Duan J-G, Cai M-C, Zhao S-N, Cidanpingcuo, Tu Y-Q, Wu SF, Yao Y-G, Bandelt H-J, Zhang Y-P. 2009. Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau. Proceedings of the National Academy of Sciences of the United States of America, 106: 21230-21235. 

69. Bandelt H-J, Salas A, Taylor RW, Yao Y-G*. 2009. The exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searches. Human Mutation, 30: 191-196. 

70. Zhang A-M, Zou Y, Guo X, Jia X, Zhang Q*, Yao Y-G*. 2009 Mitochondrial DNA mutation m.3635G>A may be associated with Leber hereditary optic neuropathy in Chinese. Biochemical and Biophysical Research Communications, 386: 392–395. 

71. Chen S-Y, Huang Y, Zhu Q, Fontanesi L, Yao Y-G*, Liu Y-P*. 2009. Sequence characterization of the MC1R gene in yak (Poephagus grunniens) breeds with different coat colours. Journal of Biomedicine and Biotechnology, Volume 2009, Article ID 861046; doi: 10.1155/2009/861046. 

72. Zhang Z-R, Liu Y-P, Yao Y-G, Jiang X, Du H, Zhu Q. 2009. Identification and association of the single nucleotide polymorphisms in calpain3 (CAPN3) gene with carcass traits in chickens. BMC Genetics, 10: 10; doi: 10.1186/1471-2156-10-10. 

73. Bandelt H-J, Yao Y-G, Bravi CM, Salas A, Kivisild T. 2009. Median network analysis of defectively sequenced entire mitochondrial genomes from early and contemporary disease studies. Journal of Human Genetics, 54:174-181. 

74. Liu Y-P, Cao S-X, Chen S-Y, Yao Y-G, Liu T-Z. 2009. Genetic diversity of Chinese domestic goat based on the mitochondrial DNA sequence variation. Journal of Animal Breeding and Genetics, 126: 80-89 

75. Ji Y, Zhang A-M, Jia X, Zhang Y-P, Xiao X, Li S, Guo X, Bandelt H-J, Zhang Q, Yao Y-G*. 2008. Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber Hereditary Optic Neuropathy in Chinese families with the m.11778G→A mutation. American Journal of Human Genetics, 83: 760-768. 

76. Yao Y-G*, Kong Q-P, Salas A, Bandelt H-J. 2008. Pseudo-mitochondrial genome haunts disease studies. Journal of Medical Genetics, 45: 769-772. 

77. He D-Q, Zhu Q, Chen S-Y, Wang H-Y, Liu Y-P*, Yao Y-G*. 2008. A homogenous nature of Chinese native duck matrilineal pool. BMC Evolutionary Biology, 8: 298; doi: 10.1186/1471-2148-8-298. 

78. Bandelt H-J, Yao Y-G, Richards M, Salas A. 2008. The brave new era of human genetic testing. BioEssays, 30: 1246-1251. 

79. Kong Q-P, Salas A, Sun C, Fuku N, Tanaka M, Zhong L, Wang C-Y, Yao Y-G, Bandelt H-J. 2008. Distilling artificial recombinants from large sets of complete mtDNA genomes. PLoS ONE, 3:e3016; doi: 10.1371/journal.pone.0003016. 

80. Zhang A-M, Jia X, Yao Y-G*, Zhang Q*. 2008. Co-occurrence of A1555G and G11778A in a Chinese family with high penetrance of Leber's hereditary optic neuropathy. Biochemical and Biophysical Research Communications, 376: 221-224. 

81. Wang H-W, Jia X, Ji Y, Kong Q-P, Zhang Q*, Yao Y-G*, Zhang Y-P. 2008. Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is independent of mtDNA haplogroup background and secondary mutation G13708A. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 643: 48-53. 

82. Bandelt H-J, Yao Y-G, Salas A. 2008. The search of 'novel' mtDNA mutations in hypertrophic cardiomyopathy: MITOMAPping as a risk factor. International Journal of Cardiology, 126: 439-442. 

83. Chen S-Y, Liu Y-P, Wang W, Gao C-Z, Yao Y-G, Lai S-J. 2008. Dissecting the matrilineal components of Tongjiang cattle from southwest China. Biochemical Genetics, 46: 206-215. 

84. Ji Y, Jia X, Zhang Q, Yao Y-G. 2007. mtDNA haplogroup distribution in Chinese patients with Leber’s hereditary optic neuropathy and G11778A mutation. Biochemical and Biophysical Research Communications, 364: 238-242. 

85. Wu G-S, Yao Y-G, Qu K-X, Ding Z-L, Li H, Palanichamy Mg, Duan Z-Y, Li N, Chen Y-S, Zhang Y-P. 2007. Population phylogenomic analysis of mitochondrial DNA in wild boars and domestic pigs revealed multiple domestication events in East Asia. Genome Biology, 8:R245; doi: 10.1186/gb-2007-8-11-r245. 

86. Yao Y-G*, Childs RW, Kajigaya S, McCoy JP, Jr, Young NS. 2007. Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation. Stem Cells, 25:2670-2676 

87. Yao Y-G*, Bandelt H-J, Young NS. 2007. External contamination in single cell mtDNA analysis. PLoS ONE, 2: e681; doi: 10.1371/journal.pone.0000681. 

88. Wang C-Y, Wang H-W, Yao Y-G, Kong Q-P, Zhang Y-P. 2007. Somatic mutations of mitochondrial genome in early stage breast cancer. International Journal of Cancer, 121: 1253-1256. 

89. Bandelt H-J, Olivieri A, Bravi C, Yao Y-G, Torroni A, Salas A. 2007. ‘Distorted’ mitochondrial DNA sequences in schizophrenic patients. European Journal of Human Genetics, 15: 400-402. 

90. Yao Y-G*, Ogasawara Y, Kajigaya S, Molldrem JJ, Falcão RP, Pintão M-C, McCoy JC, Jr, Rizzatti EG, Young NS*. 2007. Mitochondrial DNA sequence variation in single cells from leukemia patients. Blood, 109: 756-762. 

91. Yao Y-G*, Ellison FM, McCoy JP, Jr, Chen J, Young NS. 2007. Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background. Human Molecular Genetics, 16: 286-294. 

92. Lai S-J, Chen S-Y, Liu Y-P, Yao Y-G. 2007. Mitochondrial DNA sequence diversity and origin of Chinese domestic yak. Animal Genetics, 38: 77-80. 

93. Bandelt H-J, Yao Y-G, Salas A, Kivisild T, Bravi CM. 2007. High penetrance of sequencing errors and interpretative shortcomings in mtDNA sequence analysis of LHON patients. Biochemical and Biophysical Research Communications, 352: 283-291. 

94. Wang C-Y, Kong Q-P, Yao Y-G*, Zhang Y-P. 2006. MtDNA mutation C1494T, haplogroup A, and hearing loss in Chinese. Biochemical and Biophysical Research Communications, 348: 712-715. 

95. Man X-Y, Yang X-H, Cai S-Q, Yao Y-G, Zheng M. 2006. Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis. Molecular Medicine, 12: 127-136. 

96. Yang X-H, Man X-Y, Cai S-Q, Yao Y-G, Bu Z-Y, Zheng M. 2006. Expression of VEGFR-2 on HaCaT cells is regulated by VEGF and plays an active role in mediating VEGF induced effects. Biochemical and Biophysical Research Communications, 349: 31-38. 

97. Kong Q-P, Bandelt H-J, Sun C, Yao Y-G, Salas A, Achilli A, Wang C-Y, Zhong L, Zhu C-L, Wu S-F, Torroni A, Zhang Y-P. 2006. Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations. Human Molecular Genetics, 15: 2076-2086. 

98. Yao Y-G*, Salas A, Bravi CM, Bandelt H-J. 2006. A reappraisal of complete mtDNA variation in East Asian families with hearing impairment. Human Genetics, 119: 505-515. 

99. Salas A, Yao Y-G, Bandelt H-J. 2006. Mitochondria: more than mitochondrial DNA in cancer - author’s reply. PLoS Medicine, 3: e166; doi: 10.1371/journal.pmed.0030166 (comment). 

100. Sun C, Kong Q-P, Palanichamy MG, Agrawal S, Bandelt H-J, Yao Y-G, Khan F, Zhu C-L, Chaudhuri TK, Zhang Y-P. 2006. The dazzling array of basal branches in the mtDNA macrohaplogroup M from India as inferred from complete genomes. Molecular Biology and Evolution, 23: 683-690. 

101. Palanichamy MG, Agrawal S, Yao Y-G, Kong Q-P, Sun C, Khan F, Chaudhuri TK, Zhang Y-P. 2006. Comment on ‘‘Reconstructing the origin of Andaman islanders’’. Science, 311: 470; doi: 10.1126/science.1120176 (comment). 

102. Liu Y-P, Zhu Q, Yao Y-G*. 2006. Genetic relationship of Chinese and Japanese gamecocks revealed by mtDNA sequence variation. Biochemical Genetics, 44: 19-29. 

103. Liu Y-P, Wu G-S, Yao Y-G, Miao Y-W, Luikart G, Baig M, Beja-Pereira A, Ding Z-L, Palanichamy MG, Zeng F-T, Qiu X-P, Zhang Y-P. 2006. Multiple maternal origins of chickens: out of the Asian jungles? Molecular Phylogenetics and Evolution, 38: 12-19. 

104. Lai S-J, Liu Y-P*, Liu Y-X, Li X-W, Yao Y-G*. 2006. Genetic diversity and origin of Chinese cattle revealed by mtDNA D-loop sequence variation. Molecular Phylogenetics and Evolution, 38: 146-154. 

105. Salas A, Yao Y-G, Macaulay V, Vega A, Carracedo A, Bandelt H-J. 2005. A critical reassessment of the role of mitochondria in tumorigenesis. PLoS Medicine, 2: e296; doi: 10.1371/journal.pmed.0020296 

106. Bandelt H-J, Achilli A, Kong Q-P, Salas A, Lutz-Bonengel S, Sun C, Zhang Y-P, Torroni A, Yao Y-G. 2005. Low “penetrance” of phylogenetic knowledge in mitochondrial disease studies. Biochemical and Biophysical Research Communications, 333: 122-130. 

107. Yao Y-G, Yang HS, Cao Z, Danielsson J, Duh EJ. 2005. Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism. FEBS Letters, 579: 1227-1234 

108. Bandelt H-J, Yao Y-G, Kivisild T. 2005. Mitochondrial genes and schizophrenia. Schizophrenia Research, 72: 267-269. 

109. Yao Y-G, Kong Q-P, Wang C-Y, Zhu C-L, Zhang Y-P. 2004. Different matrilineal contributions to genetic structure of ethnic populations in Silk-Road region in China. Molecular Biology and Evolution, 21: 2265-2280. 

110. Yao Y-G, Duh EJ. 2004. VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis? Biochemical and Biophysical Research Communications, 321: 648-656. 

111. Yao Y-G, Bravi CM, Bandelt H-J. 2004. A call for mtDNA data quality control in forensic science. Forensic Science International, 141: 1-6. 

112. Kong Q-P, Yao Y-G, Sun C, Zhu C-L, Zhong L, Wang C-Y, Cai W-W, Xu X-M, Xu A-L, Zhang Y-P. 2004. Phylogeographic analysis of mitochondrial DNA haplogroup F2 in China reveals T12338C in the initiation codon of the ND5 gene not to be pathogenic. Journal of Human Genetics, 49: 414-423. 

113. Duh EJ, Yao Y-G, Dagli M, Goldberg MF. 2004. Persistence of fetal vasculature in a patient with Knobloch Syndrome: potential role for endostatin in fetal vascular remodeling of the eye. Ophthalmology, 111: 1885-1888. 

114.   Luan Y-X, Yao Y-G, Xie R-D, Yang Y-M, Zhang Y-P, Yin W-Y. 2004. Analysis of 18S rRNA gene of Octostigma sinensis (Projapygoidea: Octostigmatidae) supports the monophyly of Diplura. Pedobiologia, 48: 453-459. 

115. Yao Y-G*, Macaulay V, Kivisild T, Zhang Y-P, Bandelt H-J. 2003. To trust or not to trust an idiosyncratic mitochondrial data set. American Journal of Human Genetics, 72: 1341-1346. 

116. Yao Y-G*, Macaulay V, Kivisild T, Zhang Y-P, Bandelt H-J. 2003. Mitochondrial DNA variation in Amerindians - Reply to Silva et al. American Journal of Human Genetics, 72: 1348-1349 (comment). 

117. Yao Y-G, Zhang Y-P. 2003. Pitfalls in the analysis of ancient human mtDNA. Chinese Science Bulletin, 48: 826-830. 

118. Yao Y-G, Kong Q-P, Sun C, Zhang Y-P. 2003. Can the occurrence of rare insertion/deletion polymorphisms in human mtDNA be verified from phylogeny? Chinese Science Bulletin, 48: 663-667. 

119. Yao Y-G, Kong Q-P, Man X-Y, Bandelt H-J, Zhang Y-P. 2003. Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA. Molecular Biology and Evolution, 20: 214-219. 

120. Kong Q-P, Yao Y-G, Liu M, Chen C, Zhu C-L, Palanichamy MG, Zhang Y-P. 2003. Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China. Human Genetics, 113: 391-405. 

121. Kong Q-P, Yao Y-G, Sun C, Bandelt H-J, Zhu C-L, Zhang Y-P. 2003. Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences. American Journal of Human Genetics, 73: 671-676. 

122. Bandelt H-J, Herrnstadt C, Yao Y-G, Kong Q-P, Kivisild T, Rengo C, Scozzari R, Richards M, Villems R, Macaulay V, Howell N, Torroni A, Zhang Y-P. 2003. Identification of Native American founder mtDNAs through the analysis of complete mtDNA sequences: some caveats. Annals of Human Genetics, 67: 512-524. 

123. Kong Q-P, Yao Y-G, Huang S-Y, Huang J-F, Zhang Y-P. 2003. Mitochondrial DNA control region and cytochrome b sequence variation in the genus Mystacoleucus Günther (Pisces: Cyprinidae: Barbinae) from China. Biochemical Genetics, 41: 305-313. 

124. Man X-Y, Luo H-R, Li X-P, Yao Y-G, Mao C-Z, Zhang Y-P. 2003. Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese. Annals of the Rheumatic Diseases, 62: 71-73. 

125. Yao Y-G, Kong Q-P, Bandelt H-J, Kivisild T, Zhang Y-P. 2002. Phylogeographic differentiation of mitochondrial DNA in Han Chinese. American Journal of Human Genetics, 70: 635-651. 

126. Yao Y-G, Nie L, Harpending H, Fu Y-X, Yuan Z-G, Zhang Y-P. 2002. Genetic relationship of Chinese ethnic populations revealed by mtDNA sequence diversity. American Journal of Physical Anthropology, 118: 63-76. 

127. Yao Y-G, Zhang Y-P. 2002. Phylogeographic analysis of mtDNA variation in four ethnic populations from Yunnan Province: new data and a reappraisal. Journal of Human Genetics, 47: 311-318. 

128. Yao Y-G, Kong Q-P, Zhang Y-P. 2002. Mitochondrial DNA 5178A polymorphism and longevity. Human Genetics, 111: 462-463. 

129. Luo H-R, Lü X-M, Yao Y-G, Horie N, Takeishi K, Jorde LB, Zhang Y-P. 2002. Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles. Biochemical Genetics, 40: 41-51. 

130. Zhang Y-W, Fang Y-H, Long H-S, Yao Y-G, Cai Q, Zhang Y-P. 2002. Sequence variation of rbcL gene and evolution of Saccharum and related species. Acta Botanica Yunnanica, 24: 29-36 (In English with Chinese abstract). 

131. Yao Y-G, Yuan Z-G, Zhou Z-D, Geng P-L, Li Q-W, Zhang Y-P. 2001. Frequency of the mtDNA 9-bp deletion in Chinese ethnic groups. Progress in Natural Science, 11: 358-364. 

132. Yang Z-Q, Zuo Y-X, Yao Y-G, Chen X-W, Yang G-C, Zhang Y-P. 2001. Analysis of the 18S rRNA genes of Sarcocystis species suggests that the morphologically similar organism from cattle and water buffalo should be considered the same species. Molecular and Biochemical Parasitology, 115: 283-288. 

133. Yao Y-G, Kong Q-P, Zhang Y-P. 2001. Methods and thoughts on detecting nucleotide variation in human mitochondrial DNA. Zoological Research, 22: 321-331 (In Chinese). 

134. Yuan Z-G, Yao Y-G, Ma Z-X, Pang Q-P, Jie Y-R, Ma J, Zhang Y-P. 2001. Mitochondrial DNA sequence variations of Zhuang ethnic group in Guangxi. Acta Genetica Sinica, 28:95-102 (In Chinese). 

135. Yu Y-S, Yao Y-G, Kong Q-P, Rong J-Q, Luo Z-G, Ren G-X, Zhang Y-P. 2001. Mitochondrial DNA sequence variations of Shui ethnic group. Acta Genetica Sinica, 28: 691-698 (In Chinese). 

136. Yao Y-G, Watkins WS, Zhang Y-P. 2000. Evolutionary history of the mtDNA 9-bp deletion in Chinese populations and its relevance to the peopling of East and Southeast Asia. Human Genetics, 107: 504-512. 

137. Yao Y-G, Lü X-M, Luo H-R, Li W-H, Zhang Y-P. 2000. Gene admixture in the silk road of China: evidence from mtDNA and melanocortin 1 receptor polymorphism. Genes & Genetic Systems, 75: 173-178. 

138. Ding Y-C, Wooding S, Harpending H, Chi H-C, Li H-P, Fu Y-X, Pang J-F, Yao Y-G, Xiang YJG, Moyzis R, Zhang Y-P. 2000. Population structure and history in East Asia. Proceedings of the National Academy of Sciences of the United States of America, 97: 14003-14006. 

139. Yao Y-G, Zhang Y-P. 2000. Mitochondrial DNA and human evolution. Zoological Research, 21: 392-406 (In Chinese). 

140. Zhou J-L, Yao Y-G, Huang M-H, Yang D-T, Lü S-Q, Zhang Y-P. 2000. Phylogenetic relationships among Viperidae, Crotalinae based on mitochondrial 12S rRNA sequence variations. Acta Genetica Sinica, 27: 283-289 (In Chinese). 

  Research Team:

Laboratory  Staff 

Ms. Dan-Dan Yu, Research Associateyudandan@mail.kiz.ac.cn 

Dr. Wen Zhang, Research Associatezhangwen@mail.kiz.ac.cn 

Dr. Dong Wang, Research Associatewangdong@mail.kiz.ac.cn 

Ms. Lu-Xiu Yang, Technicianyangluxiu@mail.kiz.ac.cn 

Postdoctoral Fellow 

Hao Guo 

Graduate Students 

Liang MaRui BiLing XuDeng-Feng ZhangYu FanLing-Yan SuQiu-Xiang HuHui-Zhen WangLi LvXiao LiYong WuQun XiangLi PengGuo-Dong LiMin Xu 

 
  Home Mail Login Intranet login Living and Working in Kunming
Copyright© Kunming Institute of Zoology Chinese Academy of Sciences .All Rights Reserved
Address:No.32 Jiaochang Donglu Kunming 650223 Yunnan,China
Tel:+86 871 65130513 Fax:+86 871 65191823 【mail】