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Principal Investigator
Wen Wang   Ph.D  
Title Professor
Phone +86 871 65193359
Fax +86 871 65193359
E-mail wwang@mail.kiz.ac.cn
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Zip Code 650203
 
   Education and Appointments:
Wen Wang, doctoral supervisor, principle investigator, CAS. Head of CAS–Max Planck Junior Research Group, Kunming Institute of Zoology, CAS. Deputy Director of Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution.

    

  Professional Experience 

  2002.8-present, Leader of Max Planck Junior Scientist Group, Kunming Institute of Zoology, CAS 

  2002.8-2014.1, Deputy Director of Kunming Institute of Zoology, CAS 

  1997.9-2002.7, Research Associate at Department of Ecology & Evolution, The University of Chicago, USA 

  1995.10-1996.6, Visiting student at Center for Environmental Research and Conservation, Columbia University, New York, USA. 

  1992.12-1996.9 , Ph.D., Kunming Institute of Zoology, CAS, Supervisors: Shi Liming and Wu Heling. 

  1985.9-1989.7,  B.Sc. of Cell Biology, Department of Biology, Wuhan University, China 

  Professional Services
   Research Interests:

In the post genomic era, to delineate numerous data is both a popular topic and a challenging scientific task. Our laboratory focuses on the study of genome in evolution, such as new structures in genomes and evolutionary mechanisms of their new functions. Specifically, our research interests include revealing mechanisms of new genes’ origination and evolution, using new genes as the system to study formation and evolution of new pathways and gene networks. Through the approaches from genetic, evolutionary and developmental studies, we aim to elucidate relationship between genotypes and formation of phenotypes, and adaptation of organisms.
   Research focus

1. Mechanisms of new gene origination and evolution
2. General patterns of formation and development of new pathways and gene networks
3. Mechanisms of artificial selection and genomic evolution 
4. Evolution of mammalian neo-sex chromosomes, animal toxin genes, new exons and others

  Supported Projects:

funds

projects

time

Chief Researcher

National Natural Science Foundation of China-Innovative team project

Origin of genetic novelties in genomes and their significance in the evolution and adaptation of animals

2014.12016.12

Wen Wang

Leading person project from Yunnan Science and Technology Department

The genomic and molecular basis of genetic novelties in animals and economic plants

2013.12017.12

Wen Wang

National "973" Key Basic Research Project

Genetic and genomic evolution of our native domesticates under artificial selection

2013.1.12017.8

Wen Wang

National Natural Science Foundation of China- key project

The role of new genes in development and evolution of fruit fly

2010.1?2013.12

Wen Wang

National Natural Science Foundation of China- key project

The role of new genes in development and evolution of fruit fly

2010.1?2013.12

Wen Wang

National Natural Science Foundation of China- momentous Research Project

Epigenetic changes of silkworm genome during domestication

2010.1?2013.12

Wen Wang

Key project of applied foundation research , Yunnan province

Function identification of rice genetic resource in large-scale

2009.12011.12

Wen Wang

key project of transgenic new varieties culture

Large-scale identification of rice gene of economic traits by evolutionary genomic research

2009.12010.12

Wen Wang

National Natural Science Foundation of China- project of free application

Eigenomic change of silk-worm in artificial selection

2009.12011.12

Hui Xiang

National Natural Science Foundation of China-project for yong scientists fund

origination and Evolution of stem cell-related genes

2009.12011.12

Ren Lichen

National "973" Key Basic Research Project

artificial selection and genomic evolution

2007.7?2011.8

Wen Wangchief scientist

The key Knowledge Innovation Project, CAS

 

new gene origination and evolution in animal development

2007.102010.10

Wen Wang

  Public Services:
  Honors:

2012 National Natural Science Award (Second grade Prize)

2010 Natural Science Award of Yunnan Province (First grade Prize)

2008 K.C.Wong Outstanding Contribution Award of the Chinese Academy of Sciences for western scholars

2007 Supported by the National "973" Key Basic Research Project as the Chief Scientist

2005 Supported by the Key Project of National Natural Science Foundation of China

2004 National Outstanding Youth Funds

2004 Selected in the first national list of the Trans-century(Hundred, Thousand and Ten Thousand)Talents Project

  Selected Publications:

代表性论文 (*通讯作者)

1、    Chen L, Qiu Q, Jiang Y, Wang K, Lin ZH, Li ZP, Bibi F, Yang YZ, Wang JH, Nie WH, Su WT, Liu GC, Li QY, Fu WW, Pan XY, Liu C, Yang J, Zhang CZ, Yin Y, Wang Y, Zhao Y, Zhang C, Wang ZK, Qin YL, Liu W, Wang B, Ren YD, Zhang R, Zeng Y, Fonseca R.R, Wei B, Li R, Wan WT, Zhao RP, Zhu WB, Wang YT, Duan SC, Gao Y, Zhang Y, Chen CY, Hvilsom C, Epps C, Chemnick L, Dong Y, Mirarab S, Siegismund H, Ryder O, Gilbert M, Lewin H, Zhang GJ*, Heller R*, Wang W*. 2019. Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits, Science, 364(6446), 2019. (Research Article) (DOI: 10.1126/science.aav6202).

2、    Wang Y, Zhang CZ, Wang NN, Li ZP, Heller R, Liu R, Zhao Y, Han JG, Pan XY, Zheng ZQ, Dai XQ, Chen CS, Dou ML, Peng SJ, Chen XQ, Liu J, Li M, Wang K, Liu C, Lin ZS, Chen L, Hao F, Zhu WB, Song CC, Zhao C, Zheng CL, Wang JM, Hu SW, Li CY, Yang H, Jiang L, Li GY, Liu MJ, Sonstegard T, Zhang GJ, Jiang Y*, Wang W*, Qiu Q*. 2019. Genetic basis of ruminant headgear and rapid antler regeneration, Science, 364(6446), 2019. (Research Article) (DOI: 10.1126/science.aav6335).

3、    Lin ZS, Chen L, Chen XQ, Zhong YB, Yang Y, Xia WH, Liu C, Zhu WB, Wang H, Yan BY, Yang YF, Liu X, Kvie K, R?ed K, Wang K, Xiao WH, Wei HJ, Li GY, Heller R, Gilbert M, Qiu Q*, Wang W*, Li ZP*. 2019. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus), Science, 364(6446), 2019. (Research Article) (DOI: 10.1126/science.aav6312).

4、    Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W*, Qiu Q*, He S*. 2019. Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation. Nature Ecology Evolution (2019). 3: 823–833 

5、    Liu GC#, Chang Z#, Chen L#, He JW#, Dong ZW, Yang J, Lu SH, Zhao RP, Wan WT, Zhang R, Wang W*, Li XY*. 2019. Genome size variation in butterflies (Insecta, Lepidotera, Papilionoidea): A thorough phylogenetic comparison. Systematic Entomology. In press.

6、   Lu SH#, Yang J#, Dai XL#, Xie FA, He JW, Dong ZW, Mao JL, Liu GC, Chang Z, Zhao RP,  Wan WT, Zhang R, Wang W*, Li XY*. 2019. Chromosomal-level reference genome of Chinese peacock butterfly (Papilio bianor) based on third-generation DNA sequencing and Hi-C analysis. GigaScience. 8 (11): pii: giz128. (doi: 10.1093/gigascience/giz128)

7、    Liu GC#, Dong ZW#, Hou QB#, He JW, Zhao RP, Wang W, Li XY*. 2019. Second rhagophthalmid luciferase cloned from Chinese glow-worm Menghuoius giganteus (Rhagophthalmidae: Elateroidea). Photochem Photobiol. (doi: 10.1111/php.13172)

8、    Chen X#, Dong ZW#, Liu GC#, He JW, Zhao RP, Wang W*, Pen YQ*, Li XY*. 2019. Phylogenetic analysis provides insights into the evolution of Asian fireflies and adult bioluminescence. Molecular Phylogenetics and Evolution 140, 106600. (doi:10.1016/j.ympev.2019.106600)

9、    Liu GC#, Zhang R#, Hou QB, He JW, Dong ZW, Zhao RP, Wang W, Li XY*. 2019. Cloning and characterization of luciferase from the Chinese firefly Lamprigera yunnana. Photochem Photobiol. 95(5):1186-1194. (2018, IF=2.22) (https://doi.org/10.1111/php.13109)

10、He JW#, Bi WX#, Dong ZW, Liu GC, Zhao RP, Wang W*, Li XY*. 2019. The mitochondrial genome of the first luminous click-beetle (Coleoptera: Elateridae) recorded in Asia. Mitochondrial DNA Part B-Resources. 4 (1): 565-567. (2017, IF=0.488). (https://doi.org/10.1080/23802359.2018.1555019)

11、Liu GC, Dong ZW, He JW, Zhao RP, Wang W, Li XY*. 2017. Genome size of 14 species of fireflies (Insecta, Coleoptera, Lampyridae). Zoological Research (2017, 38 (6): 449-458). (DOI: 10.24272/j.issn.2095-8137.2017.078.) (SCI-E).

12、Li XY#, Liu GC#, Sheng WJ#, Dong ZW, Chen L, Zhao RP, Wang W*. 2017. Genome editing in the butterfly type-species Papilio machaon. Insect Science. 24, 708-711, DOI10.1111/1744-7917.12421.

13、Li XY#, Fan DD#, Zhang W#, Liu GC#, Zhang L#, Zhao L, Fang X, Chen L, Dong Y, Chen Y, Ding Y, Zhao RP, Feng MJ, Zhu Y, Feng Y, Jiang XT, Zhu DY, Xiang H, Feng XK, Li SC, Wang J, Zhang GJ, Kronforst MR *, Wang W*. 2015. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nature Communications, 6: 8212.

14、Zhou Z, Jiang Y, Wang Z, Gou Z, Lyu L, Li W, Yu Y, Shu L, Zhao Y, Ma Y, Fang C, Shen Y, Liu T, Li C, Li Q, Wu M, Wang M, Wu Y, Dong Y, Wan W, Wang X, Ding Z, Gao Y, Xiang H, Zhu B, Lee S-H, Wang W*, Tian Z*. 2015. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature Biotechnology (2015), 33 (4): 408-414.

15、Jiang Y, Xie M, Chen WB, Talbot R, Maddox JF, Faraut T, Wu CH, Muzny DM, Li YX, Zhang WG, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SMJ, Adelson DL, Bian C, Cam GR, Chen YL, Cheng SF, DeSilva U, Dixen K, Dong Y, Fan GY, Franklin IR, Fu SY, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang GD, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu WQ, Liu X, Lu CX, Lv T, Mathew T, McWilliam S, Menzies M, Pan SK, Robelin D, Servin B, Townley D, Wang WL, Wei B, White SN, Yang XH, Ye C, Yue YJ, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W*, Dalrymple BP*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science (2014) 344: 1168-73.

16、 Lyu J, Zhang SL, Dong Y, He WM, Zhang J, Deng X, et al, Wang W*. 2013. Analysis of elite variety tag SNPs reveals an important allele in upland rice, Nature Communications (2013) 4:2138.

17、Dong Y, Xie M, Jiang Y, Xiao NQ, Du XY, Zhang WG, Tosser-Klopp G, Wang JH, Yang S, Liang J, Chen WB, Chen J, Zeng P, Hou Y, Bian C, Pan SK, Li YX, Liu X, Wang WL, Servin B, Sayre B, Zhu B, Sweeney D, Moore R, Nei WH, Shen YY, Zhao RP, Zhang GJ, Li JQ, Faraut T, Womack J, Zhang YP, Kijas J, Cockett N, Xu X, Zhao SH, Wang J*, Wang W*. 2013. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nature Biotechnology (2013) 31: 135-141.

18、Ding Y, Zhou Q, Wang W*. 2012. Origins of New Genes and Evolution of their Novel Functions. Annual Review of Ecology, Evolution, and Systematics (2012) 43: 345-363(invited review).

19、Xu X, Liu X, Ge S, Jensen D J, Hu FY, Li X, Dong Y, Gutenkunst NR, Fang L, Huang Li, Li JX, He WM , Zhang GJ, Zheng XM, Zhang FM,Li YR, Yu C, Kristiansen K, Zhang XQ, Wang J, Wright M, McCouch S, Nielsen R, Wang J, Wang W*. 2012. Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nature Biotechnology (2012) 30: 105-111.

20、Xiang H, Zhu JD, Chen Q, Dai FY, Li X, Li MW, Zhang HY, Zhang GJ, Li D, Dong Y, Zhao L, Lin Y, Cheng DJ, Yu J, Sun JF, Zhou XY, Ma KL, He YH, Zhao YX, Guo SC, Ye MZ, Guo GW, Li YR, Li RQ, Zhang XQ, Ma LJ, Kristiansen K, Guo QH, Jiang JH, Beck S, Xia QY*, Wang W*, Wang J*. 2010. Single base–resolution methylome of the silkworm reveals a sparse epigenomic map. Nature Biotechnology (2010) 28: 516-520.

21、Zhou Q, Zhang G, Xu S, Zhao R, Li X, Ding Y, Wang W*. 2008. On the origin of new genes in Drosophila. Genome Research (2008) 18:1446-1455.

22、Li X, Liang J, Yu H, Su B, Xiao C, Shang YF*, Wang W*. 2007. Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics (2007) 23: 427-431.

23、Wang W *et al. 2005. Origin and Evolution of New Exons in Rodents. Genome Research (2005) 15: 1258-1264.

24、Wang W, Yu H, Long M. 2004. Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila. Nature Genetics (2004) 36: 523-527.

25、Wang W, Brunet FG, Nevo E, Long M. 2002. Origin of Sphinx, a young chimeric RNA gene in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA (2002) 99: 4448-4453.

26、Wang W, Thornton K, Berry A, Long M. 2002. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Science (2002) 295: 134-137.

 

  Research Team:
 
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