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Principal Investigator
Jian-Fan Wen   Ph.D  
Title Vice-director of the State Key Lab
Phone +86 871 65198682
Fax +86 871 65198682
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 17 Longxin Road, Kunming, Yunnan, 650201, P.R.China
Zip Code 650201
   Education and Appointments:

Current Position:  

Principal Investigator, Research Professor, Vice-director of the State Key Lab 

Education :  

1996– Ph.D. in Zoology, Kunming Institute of Zoology, CAS. 

1989 - Master of Science, Kunming Institute of Zoology, CAS. 

1986 - Bachelor of Science, Hunan Normal University.
  Professional Services
   Research Interests:

Our group is mainly interested in the origin and evolution of the eukaryotic cells. Mainly taking protists, especially those occupying very key positions in the eukaryotic cell evolution such as Giardia, unicellular green algae, as models, and combining with the data of prokaryotes and multicellular organisms, at cellular and molecular levels, they study the origin and evolution of the structures, functions, genes, gene families, and genome of the eukaryotic cell. They also study the adaptive evolution of parasites (parasitic protozoans and flatworms) and algae (green algae), especially of their metabolisms, to discovery molecular targets for parasitism controlling and to develop applications of the effective and specific metabolic pathways of beneficial organisms. .

  Supported Projects:

973 program;the National Natural Science Foundation of China;the Knowledge Innovation Program of the Chinese Academy of Sciences;Grants from the NSFC;Grants from Yunnan province;the Chinese Academy of Sciences;the Key Research Program of the Chinese Academy of Sciences;the Science Foundation of Yunnan Province

  Public Services:
1) 2006, Yunnan Province Award for Natural Sciences: The origin and evolution of nuclear matrix and lamina. (second class)

2) 2000, Beijing Science and Technology Advancement Award: The isolation, gene type and nucleus of Giardia from China. (second class)3) 1999, Yunnan Province Award for Natural Sciences: The phylogeny of dinoflagellates. (second class)

  Selected Publications:

1.    Feng JM, Yang CL, Tian HF, Wang JX, Wen JF*. Identification and evolutionary analysis of the nucleolar proteome of Giardia lamblia. BMC Genomics. 2020, 21(1):269.

2.    Lyu ZX, Shao JR , Xue M, Ye QQ , Chen B, Qin Y, Wen JF*. A new species of Giardia Künstler, 1882 (Sarcomastigophora: Hexamitidae) in hamsters. Parasites & Vectors. 2018, 11(1): 202.

3.    Xue M, Chen B, Ye QQ, Shao JR, Lyu ZX, Wen JF*. Sense-antisense gene overlap is probably a cause for retaining the few introns in Giardia genome and the implications. Biology Direct. 2018, 13:23.

4.    Ye QQ, Tian HF, Chen B, Shao JR, Qin Y, Wen JF*. Giardias primitive GPL biosynthesis pathways with parasitic adaptation ‘patches’: implications for Giardias evolutionary history and for finding targets against Giardiasis. Sci Rep. 2017, 7(1):9507.

5.    Feng JM, Tian HF, Wen JF*. Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus. Genome Biol Evol. 2013, 5(12):2255-67.

6.    Tian HF, Feng JM, Wen JF*. The evolution of cardiolipin biosynthesis and maturation pathways and its implications to the evolution for eukaryotes. BMC Evol. Biol. 2012, 12:32.

7.    Jiang YH, Wang DY, Wen JF*. The independent prokaryotic origins of eukaryotic fructose-1 6-bisphosphatase and sedoheptulose-1 7-bisphosphatase and the implications of their origins for the evolution of eukaryotic Calvin cycle. BMC Evol. Biol. 2012, 12:208.

8.    Sun J, Jiang HF, Flores R, Wen JF*. Gene duplication in the genome of parasitic Giardia lamblia. BMC Evol. Biol. 2012, 10:49.

9.    Gao S, Xiong J, Zhang CC, Berquist BR, Yang RD, Zhao M, Molascon AJ, Kwiatkowski SY, Yuan DX, Qin ZH, Wen JF, Kapler G-M, Andrews P-C, Miao W*, Liu Y-F*. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes Dev. 2013, 27(15):1662-79.

10. Lin XD, Guo WP, Wang W, Zou Y, Hao ZY, Zhou DJ, Dong X, Qu Y-G, Li MH,. Tian HF, Wen JF, Alexander Plyusnin, Xu JG, Zhang YZ*. Migration of Norway Rats Resulted in the Worldwide Distribution of Seoul Hantavirus Today. J VIROL. 2012, 86(2):972-981.

11. Ni T, Yue JP, Sun GL, Zou Y, Wen JF*, Hang J-L*. Ancient gene transfer from algae to animals: Mechanisms and evolutionary significance. BMC Evol. Biol. 2012, 12:83.

12. Zhang YJ, Tian HF, Wen JF*. The evolution of YidC/Oxa/Alb3 family in the three domains of life: a phylogenomic analysis. BMC Evol. Biol. 2009, 9:137.

13. Xin DD, Wen J-*, He D, Lu S-Q. Identification of a Giardia krr1 homolog gene and the secondarily anucleolate condition of Giaridia lamblia. Mol. Biol. Evol. 2005, 22(3): 391-394.  

14. Zhang YJ, Zhu CX, Ding YR, Yan ZW, Li GH, Lan Y, Wen JF*, Chen B*. Subcellular stoichiogenomics reveal cell evolution and electrostatic interaction mechanisms in cytoskeleton. BMC Genomic. 2018, 19(1):469.

15. Feng JM, Jiang CQ, Sun ZY, Hua CJ, Wen JF, Miao W*, Xiong J*. Single-cell transcriptome sequencing of rumen ciliates provides insight into their molecular adaptations to the anaerobic and carbohydrate-rich rumen microenvironment. Mol Phylogenet Evol. 2019, 143:106687.

  Research Team:
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