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Principal Investigator
Yun Zhang   Ph.D  
Title Professor
Phone +86 871 65198515
Fax +86 871 65198515
Address Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Zip Code 650201
   Education and Appointments:

Principal Investigator

Yun Zhang

Education and Research Positions

1999 – present: Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences, China

1998 – 1999: Visiting Scholar, Hong Kong University of Science & Technology, China

1995 – 1998:  Associate professor, Kunming Institute of Zoology, Chinese Academy of Sciences, China

1994 – 1995: Post-Doctoral Fellow, Biotoxin Unite of Pasteur Institute, Paris

1991-1992: Working in Pasteur Institute, Paris as a jointed training PhD student of Chinese Academy of Sciences and Pasteur Institute in Paris

1987 – 1992: Ph.D. student in Kunming Institute of Zoology, Chinese Academy of Sciences,   

1980 – 1984: B.S., East China University of Science and Technology, China>

  Professional Services
   Research Interests:

On one hand, receptors and ion channels are key units in cell membrane, and the dysfunction of receptors and ion channels is the important basis of human diseases, and they are major drug targets. On the other hand, living strategies for prey capture and defense have evolved extensive diverse protein and peptide toxins in venomous animals in nature. These biotoxins are characterized by 1) strong activity (acting in pM and nM); 2) high specificity (effectively on subtype of the receptors and ion channels); 3) huge molecular diversity (multiple-gene copy families). They have been widely used as 1) powerful research tools in exploring human patho-physiology, 2) important clinic therapeutics, 3) templates for clinic drug design.  

Objective: Dr. Zhang’s Lab carries out long-term, systemic research on the bio-diversity and the structure and function of protein and peptide biotoxins from various animals. At present stage, the work of Dr Zhang's Lab mainly focuses on the biotoxins from amphibians, reptiles and centipedes. Major efforts are projects that will lead to the elucidation of bio-diversity of animal toxin proteins and peptides, their biological targets, action mechanisms involved and biological implications. Such studies hopefully to provide useful information and research tools for biological and biomedical research, and will eventually help to illustrate the human patho-physiology and disease mechanisms. On the basis above, potential drug leads finding, rational new molecule design and clinic utilization are perspective. 

  Supported Projects:
  Public Services:
  Selected Publications:

(*,corresponding author) 

[1] Xiang Y, Yan C, Guo XL, Zou KF, Li SA, Gao Q, Wang X, Lee WH, and Zhang Y* (2014) Host-derived pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection. Proceedings of the National Academy of the Sciences,USA, 111, 6702-6707. 

[2] Wang YJ, Guo XL, Li SA, Zhao YQ, Liu ZC, Lee W, Xiang Y, and Zhang Y* (2014) Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1. BBA Molecular Cell Research, 1834, 1393-1401. 

[3]Zhao F, Yan C, Wang X, Yang Y, Wang GY, Lee WH, Xiang Y, Zhang Y* (2014) Comprehensive Transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system. DNA Res. 21, 1-13.  

[4]Li SA Xiang Y Lee W, Zhang Y* (2013) Naturally occurring antimicrobial peptide OH-CATH30 protects against sepsis by regulating host innate immune responses. J Med Chem 56, 9136-9145. 

[5]Du TY, Luo HM, Qin HC, Wang F, Wang Q, Xiang Y and Zhang Y* (2013) Circulating serum trefoil factor 3 (TFF3) is dramatically increased in chronic kidney disease. PLoS One 8, e80271. 

[6]Zhang Y, Wang YJ, Xiang Y, Lee WH, and Zhang Y* (2012) Prohibitins are involved in protease-activated receptor 1-mediated platelet aggregation. J Thromb. Haemosta 10, 411-418. 

[7]Yang XW, Lee WH*, and Zhang Y* (2012) Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs. J Proteome Res 11, 306-319 

[8]Liu ZC, Zhang R, Zhao F, Chen ZM, Liu HW, Wang YJ, Jiang P, Zhang Y, Wu Y, Ding JP, Lee WH and Zhang Y* (2012) Venomics and Transcriptomic Analysis of Centipede Scolopendra subspinipes dehaani. J Proteome Res 11, 6197-6212.  

[9]Zhang Y, Yu G, Wang Y, Xiang Y, Gao Q, Jiang P, Zhang J, Lee W, and Zhang Y* (2011) Activation of protease-activated receptor 1 by a frog trefoil factor and PAR4 by human trefoil factor 2. Cell Mol Life Sci 68, 3771-3780 

[10]Jiang Y, Li Y, Lee W, Xu X, Zhang Y, Zhao R, Zhang Y*, and Wang W* (2011) Venoms of two Elapid snakes (Bungarus multicinctus and Naja atra) and their evolution patterns. BMC Genomics 12, 1 

[11]Lee WH, Li Y, Lai R, Li S, Zhang Y* and Wang W* (2005) Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification. Eur J Immunol 35, 1220-1229  

[12]Lai R, Liu H, Lee WH, and Zhang Y* (2002) An anionic antimicrobial peptide from skin secretions of toad Bombina maxima. Biochem Biophys Res Commun 295, 796-799 

[13]Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, and Zhang Y* (2002) Antimicrobial peptides from the skin secretion of Chinese red belly toad Bombina maxima. Peptides 23, 427-435 

[14]Zhang Y, Wisner A, Maroun RC, Choumet V, Xiong YL, and Bon C (1997) Trimeresurus stejnegeri snake venom plasminogen activator, site-directed mutagenesis and molecular modeling. J Biol Chem 272, 20531-20537 

[15]Zhang Y, Wisner A, Xiong YL, and Bon C (1995) A novel plasminogen activator from snake venom, purification, characterization, and molecular cloning. J Biol Chem 270, 10246-10255

  Research Team:

Laboratory Staff: 

Dr. Wen-Hui Lee, Associate Professor, 

Dr. Yang -Xiang, Assistant Professor, 

Dr. Sheng-An Li, Assistant Professor, 

Dr. Yan-Jie Wang, Assistant Professor, 

Ms. Hui-Fen Wang, Secretary, 

Graduate Students: 

Feng Zhao,Xin-Wang Yang,Xiao-Long Guo, Jie Liu,Kai-Feng Zhou,Yue Zhang,Yu-Yan Zhang,Long Liu,Lin-Yan Wang,Xin-Qiang Lan,Yu-Ling Shi 

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