2002-present  Professor                  Kunming Institute of Zoology, Chinese Academy of Sciences, China 

1. Anti-HIV-1 drugs screening and the structure-activity relationship study of lead compounds  
An anti-HIV drug screening platform has been established, which includes primary screening, confirmation and specific research at the levels of molecular, cellular and AIDS primate animal models in our lab. We have widely collaborated in the study of anti-HIV drugs with 100 units from 24 provinces in China, and 6 overseas agencies from Russia, India, etc. More than 10,000 compounds purified from animals, plants, and halobios were screened for their anti-HIV-1 activities, and a series of compounds with anti-HIV-1 activities (e.g. Xanthohumol, Concentricolide and Schisandrins) were found. We have completed preclinical anti-HIV activities evaluation for 11 anti-HIV drug candidates. TCS recombinant mutant (Approval No: 2005L00148)，Sifuvirtide (Approval No: 2005L01088)，and Azvudine (Approval No: 2013L00941) has won the drug clinical trial approval document issued by CFDA. “Tangcao Pian” is the first and unique licensed TCM for AIDS in China, the Sifuvirtide recently entered phase III clinical trials in HIV-infected individuals, the Azfudine (FNC) and mTCS completed phase I clinical trial. Till now, 49 patents applications have been granted and filed. More than 150 research papers in anti-HIV drugs have been published. Our lab has become one of the main groups of anti-HIV drug research in the country now.  

2. SIV/SHIV/HIV non-human primate models for AIDS, host restriction factor, and the pathogenic mechanism of AIDS 
We have established five SIV/SHIV viruses ( including SIVmac239-, SIVmac251-, SHIV89.6-, SHIVSF162P3-, and SHIVwhu-.) infected Chinese rhesus monkey (Ch Rhs) models. In SIV/SHIV infected monkey models, our interests mainly focus on the functions of DC and Treg cells in the process, especially the early stage of simian AIDS, and the roles of old age, virus induced immune activation in disease progression. We have previously reported Northern pig-tailed macaques (Macaca leonine, NPMs) were susceptible to HIV-1 in vitro due to absence of a TRIM5 restricting protein, suggesting NPMs might be a potent animal model for HIV infection. We infected 4 Northern pig-tailed macaques with a HIV-1NL4.3 strain, and our data demonstrated HIV-1 infection was established and viruses were latent in all 4 animals. The HIV-1/HSIV infected northern pig-tailed macaques are in progress. Besides, we identified the TRIM5/TRIMCyp heterozygous genotype in M. assamensis. Recently, we found a novel mode of CypA insertion in tree shrew TRIMCyp gene fusion (ts TRIMCyp). tsTRIMCyp lost restriction ability against retroviruses and play an important role in regulating NF-κB and IFN-β promoter activation as a negative regulator. tsTRIMCyp may play a role in preventing over-reaction of innate immune response and maintaining immune balance 

3. The HIV/AIDS epidemic in Yunnan province and transmission in southwest China 
The China-Myanmar border is a particularly interesting region that has very high prevalence of and considerable diversity of HIV-1 recombinants. We found that Northern Myanmar is a big forge for HIV-1 recombination between CRF01_AE, B’, and C because the extremely high proportion of intersubtype recombinants, especially CRF01_AE/B’/C recombinants (42.6%). We also firstly represented the molecular epidemiological characterization of HIV-1 among Burmese LDTDs. High prevalence of HIV-1 CRF01_AE and inter-subtype recombinants, as well as dual infection, were detected among them. Burmese LDTDs may have made contribution in HIV-1 transmission between the heterosexuals and IDUs and between China and Myanmar in general. Co-infection with HIV and HCV and/or HBV is highly prevalent among the IDUs in the China-Myanmar border region. All infections were more prevalent among the Chinese IDUs than among the Burmese. We have isolated 421 HIV-1 clinical strains from HIV-1-infected individual in Yunnan.

Research Funding:

Major Ongoing Funding:

1.         National Natural Science Foundation of China (NSFC) (2015.1-2018.12, PI, 1.45 Million)，Establishment of functional cure macaque model and research on its viral latency mechanisms (No. 81471620).

2.         NSFC (2012.1-2015.12, PI, 0.86 Million)，Establishment of HIV/HSIV pigtailed monkey model and study of infection and immune protection mechanism (No. 81172876).

3.         NSFC (2013.1-2016.12, Co-PI, 0.86 Million)，New strategy to develop effective T-cell based based by targeting at HIV conservative epitopes (No. U1202228).

4.         Key Scientific and Technological Program of China (2012.1-2015.12, PI, 0.68 Million)， Evaluation of anti-HIV compounds (No. 2012ZX10001-006).

5.         Key Scientific and Technological Program of China (2012.1-2015.12, PI, 0.87 Million)，Preclinical evaluation of microbicide in primate models (No. 2012ZX10001-007).

6.         National Basic Research Program of China (2012.1-2016.12, PI, 1.00 Million) ，Establishment and application of HIV-1 infected pigtailed monkey model (No. 2012CBA01305).

7.         NSFC-Yunnan Joint Fund Project (2014-2017，cooperation，1.05 Million），HIV epidemic, evoluation, and Cross-border transmission of high risk population in the China-Myanmar-Vietnam-Laos border (U1302224).      

8.         NSFC (2014-2017, PI, 0.7 Million)，Study on regulation and function of HLA Iα3 deletion mutant in the immunomudulation (81373124).          

9.         NSFC (2013-2016, PI, 0.7 Million), The role and mechanism of coinfection and superinfection in hiv recombination of injection drug users in China-Myanmar border (81271892).

Major Completed Funding (past 5 years):

1.       NSFC (2007.1-2009.12, PI, 0.28 Million)，mnTRIMCyp, a novel innate immune factor and effects on HIV-1 infection (No.30671960)

2.       NSFC (2009.1-2011.12, PI, 0.30 Million)，The effect and mechanism of MamuI A isoforms on T lymphocyte proliferation and NK-mediated cytolytic activity (No.30872317)

3.       NSCF (2009.1-2012.12, PI, 1.90 Million)，Restriction and mechanism of innate immune factor TRIM5α to HIV-1 infection and replication (No. U0832601)

4.       Key Scientific and Technological Program of China (2009.1-2010.12, PI, 1.70 Million)，Isolation of clinical HIV strains in Yunnan province (2009ZX10004-902)

5.       Key Scientific and Technological Program of China (2009.1-2011.12, PI, 3.75 Million)，Establishment and application of key technologic platform for evaluation and mechanisms of anti-HIV drugs (No. 2009ZX09501-029)

6.       Knowledge Innovation Program of CAS (2011.1-2013.12, PI, 1.00 Million)，Establishment of HIV/HSIV infected northern pigtailed monkey model (KSCX2-EW-R-13)

　　2012 C.C. Tan Life Science Innovation

　　2009 The First Prize of the Yunnan Science and Technology Progress Award-“Establishment and application of key technologic platform for anti-HIV drugs”(Zheng YT, Yang LM, Wang RR, Zhang GH, Wang YH, Ouyang DY, Wang YY)

　　2009 The First Prize of the Yunnan Natural Science Awards-“The study of structure and function of active peptides from amphibious animal”(Lai R, Zhang Y, Li JX, Zhang YP, Zheng YT, Xu XQ, Yang HL, Li WH).

　　2009 The Third Prize of the Yunnan Science and Technology Progress Award-“The Construction of Yunnan HIV viruses Bank and study of molecular epidemiology”(Ma YL, Zhang Y, Lu L, Jia MH, Zheng YT, Yang L, Shi YH)

　　2009 The government of the State Council special allowance winner

　　2007 The Third Prize of Chinese Preventive Medicine Association of science and Technology Award-“The comprehensive prevention and control of HIV/AIDS in Yunnan province” (Lu L, Zheng YT, Zhou ZQ, Jia MH, Li JH, Li QS, Li Y, Ma YL)

　　2004 The Second Prize of the Yunnan Natural Science Awards-“The study of RIPs with anti-HIV activities and structure-function relationship” (Zheng YT, Ben KL ,Wang JH )

　　2004 The Outstanding Contributor for Yunnan Science and Technology

　　2002 The Young Leading Scientist Award of the Yunnan Province Government

　　1996 The First Prize of Di’ao Scholarship of the Chinese Academy of Sciences 1996 The Fong Shu-Chuen Scholarship of the Chinese Academy of Sciences

　　1996 The “Western Light” Fellowship of the Chinese Academy of Sciences

　　1995 The President of the Chinese Academy of Sciences outstanding scholarship

　　1995 The Third Prize of the Yunnan Science and Technology Progress Award-“The Diagnosis of simian AIDS and investigation of SRV infection in Chinese rhesus monkeys” (Ben KL, Chen ZB, Tian BP, Zheng YT)

　　Publications as Corresponding author: (Selected from 89 papers) 

　　[1] Mu D, Yang H, Zhu JW, Liu FL, Tian RR, Zheng HY, Han JB, Shi P*, Zheng YT*. (2014) Independent birth of a novel TRIMCyp in Tupaia belangeri with a divergent function from its paralog TRIM5. Mol Biol Evol, 2014 Aug 18. pii: msu238. [Epub ahead of print] 

　　[2] Zhou YH, Liang YB, Pang W, Qing WH, Yao ZH, Chen X, Zhang CY*, Zheng YT*. (2014) Diverse forms of HIV-1 among Burmese long-distance truck drivers implies their contribution to HIV-1 cross-border transmission. BMC Infect Dis, 2014, 14(1):463. 

　　[3] Au KY, Wang RR, Wong YT, Wong KB, Zheng YT*, Shaw PC*. (2014) Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells. BBA Gen Subjects, 1840(3):958-963 

　　[4] Dai ZX, Zhang GH, Zhang XH, Zhu JW, Zheng YT*. (2014) A splice variant of HLA-A with a deletion of exon 3 expressed as nonmature cell-surface glycoprotein forms a heterodimeric structure with full-length HLA-A. Hum Immunol, 75:234-238 

　　[5] Zhang X, Huang SZ, Gu WG, Yang LM, Chen H, Zheng CB, Zhao YX, Wan DC, Zheng YT*. (2014) Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation. Chin J Nat Med, 12(3):186-193 

　　[6] Zheng HY, Zhang MX, Pang W, Zheng YT*.  (2014) Aged Chinese rhesus macaques suffer severe phenotypic T and B-cell aging accompanied with sex differences. Exp Gerontol, 55:113-119  

　　[7] Wang RR, Yang QH, Luo RH, Peng YM, Dai SX, Zhang XJ , Chen H, Cui XQ, Liu YJ, Huang JF, Chang JB*, Zheng YT*.  (2014) Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in Vitro. PLoS One, 9(8):e105617. 

　　[8] Dai ZX, Zhang GH, Zhang XH, Zheng YT*. (2013) Identification and characterization of a novel splice variant of rhesus macaque MHC IA. Mol Immunol, 53:206-213.  

　　[9] Zhang XH, Dai ZX, Zhang GH, Han JB, Zheng YT*. (2013) Molecular characterization, balancing selection, and genomic organization of the tree shrew (Tupaia belangeri) MHC class I gene. Gene, 522(2):147-155  

　　[10] Lian W, Wu MY, Huang N, Gao N, Xiao C, Li Z, Zhang ZG, Zheng YT*, Peng WL*, Zhao JH*. (2013) Anti-HIV-1 activity and structure–activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope. BBA-Gen Subjects, 1830(10): 4681-4691.  

　　[11] Huang N, Wu MY, Zheng CB, Zhu L, Zhao JH*, Zheng YT*. (2013) The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry. Carbohyd Res, 380:64-69. 

　　[12] Cheng YY, Chen H, He HP, Zhang Y, Li SF, Tang GH, Guo LL, Yang W, Zhu F, Zheng YT*, Li SL*, Hao XJ*. (2013) Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum. Phytochemistry. 96:360-369 

　　[13] Zhang XJ, Lu LH, Wang RR, Wang YP, Luo RH, Lai CC, Yang LM, He YP*, Zheng YT*.(2013) DB-02, a C-6-cyclohexylmethyl substituted pyrimidinone HIV-1 reverse transcriptase inhibitor with nanomolar activity, displays an improved sensitivity against K103N or Y181C than S-DABOs. PLoS One, 8(11):e81489 

　　[14] Li SY, Xia HJ, Zhang GH, Dai ZX, Fan B, Li MH, Wang RR, Zheng YT*. (2012) Dynamics and functions of CD4⁺CD25^high regulatory T lymphocytes in Chinese rhesus macaques during their early stage infection with SIVmac239. Arch Virol, 157(5):961-967.  

　　[15] Zhang X, Yang LM, Liu GM, Liu YJ, Zheng CB, Lv YJ, Li HZ, Zheng YT*. (2012) Potent anti-HIV activities and mechanisms of a pine cone extract from Pinus yunnanensis. Molecules, 17(6):6916-6929. 

　　[16] Zhou YH, Yao ZH, Liu FL, Li H, Jiang L, Zhu JW, Zheng YT*. (2012) High prevalence of HIV, HCV, HBV and co-infection and associated risk factors among injecting drug users in Yunnan province, China. PLoS One, 7(8): e42937 

　　[17] Ma JP, Xia HJ, Zhang GH, Han JB, Zhang LG, Zheng YT*. (2012) Inhibitory effect of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239 infected Chinese rhesus macaques. Cell Mol Immunol, 9(5):410-416 

　　[18] Hu GP, Li X, Zhang X, Li YZ, Ma L, Yang LM, Liu GX, Li WH, Huang J, Shen X, Hu LH*, Zheng YT*, Tang Y*. (2012) Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays. J Med Chem, 55(22):10108-10117. 

　　[19] Pang W, Zhang CY, Duo L, Zhou YH, Yao ZH, Liu FL, Li H, Tu YQ, Zheng YT*. (2012) Extensive and complex HIV-1 recombination between B’, C and CRF01_AE among IDUs in Northern Myanmar. AIDS, 26(9):1121-1129 

　　[20] Dai ZX, Zhang GH, Zhang XH, Xia HJ, Li SY, Zheng YT*. (2012) The β2-microglobulin-free heterodimerization of rhesus monkey MHCⅠA with its normally spliced variant reduces the ubiquitin-dependent degradation of MHCIA. J Immunol, 188(5): 2285-2296  

　　[21] Wang RR, Gao YD, Ma CH, Zhang XJ, Huang CG, Huang JF, Zheng YT*. (2011) Mangiferin, an anti-HIV agent targeting protease effective against resistant strains. Molecules, 16:4264-4277 

　　[22] Liu FL, Qiu YQ, Li H, Kuang YQ, Tang X, Cao G, Tang NLS, Zheng YT*.(2011) An HIV-1 resistance polymorphism in TRIM5α gene among Chinese intravenous drug users. J Acquir Immune Defic Syndr, 56(4):306-311 

　　[23] Pang W, Wang RR, Gao YD, Yang LM, Sun Y, Huang JF, Tien P, Zheng YT*.(2011) A novel enzyme-linked immunosorbent assay for screening HIV-1 fusion inhibitors targeting HIV-1 Gp41 core structure. J Biomol Screen, 16(2):221-229.  

　　[24] Zhou YH, Liu FL, Yao ZH, Duo L, Li H, Sun Y, Zheng YT*. (2011) Comparison of HIV-, HBV-, HCV- and -co-infection prevalence between Chinese and Burmese intravenous drug users of the China-Myanmar border region. PLoS One, 6(1):e16349 

　　[25] He YP, Long J, Zhang SS, Li C, Lai CC, Zhang CS, Li DX, Zhang DH, Wang H, Cai QQ, Zheng YT*. (2011) Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl-cyclohexylmethyl oxopyrimidines (S-DACOs) as high active anti-HIV agents. Bioorg Med Chem Lett, 21:694-697 

　　[26] Xia HJ, Zhang GH, Ma JP, Dai ZX, Li SY, Han JB, Zheng YT*.(2010) Dendritic cell subsets dynamics and cytokine productions in SIVmac239 infected Chinese rhesus macaques. Retrovirology, 7:102 

　　[27] Law SK, Wang RR, Mak AN, Wong KB, Zheng YT*, Shaw PC*. (2010) A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells. Nucleic Acids Res, 38(19):6803-6812  

　　[28] Sun Y, Ouyang DY, Pang W, Tu YQ, Li YY, Shen XM, Tam SC, Yang HY, Zheng YT*. (2010) Expression of syncytin in leukemia and lymphoma cells. Leukemia Res, 34:1195-1202. 

　　[29] Lin HW, Sun MX, Wang YH, Yang LM, Yang YR, Huang N, Xuan LJ, Xu YM, Bai DL, Zheng YT*, Xiao K*. (2010) Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med, 76:889-892 

　　[30] Xia HJ, Zhang GH, Wang RR, Zheng YT*. (2009) The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques. Cell Mol Immunol, 6(6):433-440 

　　[31] Pang W, Tam SC, Zheng YT*. (2009) Current peptide HIV type-1 fusion inhibitors. Antivir Chem Chemoth, 20(1):1-18 

　　[32] Tu YQ, Wang MJ, Yao J, Zhu XM,  Pan PL, Xing WG, Zhang GH, Yang RG,  Zheng YT*, Jiang Y*. (2009) Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China. Transfusion, 49(9):1865-1873. 

　　[33] Xia HJ, Liu HL, Zhang GH, Zheng YT*. (2009) Phenotype and function of myeloid dendritic cells derived from Chinese rhesus macaque blood monocytes. Cell Mol Immunol, 6(3):159-165 

　　[34] Kuang YQ, Tang X, Liu FL, Jiang XL, Zhang YP, Gao GX, Zheng YT*.(2009) Genotyping of TRIM5 locus in Northern pig-tailed macaques (Macaca leonina), a primate species susceptible to human immunodeficiency virus type 1 infection. Retrovirology, 6(1):58 

　　[35] Wang RR, Yang LM, Wang YH, Pang W, Tam SC, Tien P, Zheng YT*. (2009) Sifuvirtide, a potent HIV fusion inhibitor peptide. Biochem Biophys Res Commun, 382:540-544  

　　[36] Ouyang DY, Xu LH, Dai ZX, Shi HJ, Zhang GH, Zheng YT*, He XH*. (2008) Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques. Acta Bioch Bioph Sin, 40(11):919-927. 

　　[37] Pang W, Wang RR, Yang LM, Liu CM, Tien P, Zheng YT*.(2008) Recombinant protein of Heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro. Virology, 377(1):80-87.  

　　[38] Wang RR, Gu Q, Wang YH, Zhang XM, Yang LM, Zhou J, Chen JJ, Zheng YT*. (2008) Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis. J Ethnopharmacol, 117(2):249-256 

　　[39] Liao CH, Kuang YQ, Liu HL, Zheng YT*, Su B*. (2007) A novel fusion gene mnTRIMCyp in pig-tailed macaque determines its susceptibility to HIV-1 infection. AIDS, 21(Suppl 8):S19-S26 

　　[40] Liu GJ, Wang JP, Xiao JC, Zhao ZW, Zheng YT*. (2007) Preparation and characterization of three monoclonal antibodies against HIV-1 p24 capsid protein. Cell Mol Immunol, 4(3): 203-8 

　　[41] Wang YH, Tang JG, Wang RR, Yang LM, Dong ZJ, Du L, Shen X, Liu JK, Zheng YT*.  (2007) Flazinamide, a novel β-carboline compound with anti-HIV actions. Biochem Biophys Res Commun, 355:1091-1095 

　　[42] Wang RR, Gu Q, Yang LM, Chen JJ, Li SY, Zheng YT*. (2006) Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis. J Ethnopharmacol, 105(1-2):269-273 

　　[43] Wang JH, Kong J, Li W, Molchanova V, Chikalovets I, Belogorseva N, Luk'Yabov P,. Zheng YT*. (2006) A β-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity. Comp Biochem Phys C Toxicol Pharmacol, 142(1-2):111-117 

　　[44] Ouyang DY, Chan H, Wang YY, Huang H, Tam SC, Zheng YT*.(2006) An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin. Biochem Biophys Res Commun, 339(1):25-29 

　　[45] Ouyang DY, Wang YY, Zheng YT*. (2005)Activation of c-Jun N-terminal kinases by ribotoxic stresses. Cell Mol Immunol, 2(6):419-25.  

　　[46] Liu HL, Wang YQ, Liao CH, Kuang YQ, Zheng YT*, Su B*. (2005) Adaptive evolution of primate TRIM5α, a gene restricting HIV-1 infection. Gene, 362:109-116 

　　[47] Zhao Y, Jin Y, Wang JH, Wang RR, Yang LM, Zheng YT*, Zhang Y*.(2005) A novel heme-containing protein with anti-HIV-1 activity from Bufo andrewsi skin. Toxicon, 46:619-624 

　　[48] Zhang GH, Wang Q, Chen JJ, Zhang XM, Tam SC, Zheng YT*.(2005) Anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun, 334:812-816. 

　　[49] Wang YY, Ouyang DY, Huang H, Chan H, Tam SC, Zheng YT*. (2005) Enhanced apoptotic action of trichosanthin in HIV-1 infected cells. Biochem Biophys Res Commun, 331:1075-1080. 

　　[50] Liu GJ, Yang LM, Wang JH, Zhang GH, Chen XM, Zheng YT*. (2005) Immune responses to six synthetic peptides of capsid protein with sera from HIV-1 infected individuals. Cell Mol Immunol. 2(4):289-93. 

　　[51] Wang Q, Ding ZH, Liu JK, Zheng YT*. (2004) Xanthohumol, a novel anti-HIV-1 agent purified from Hop Humulus lupulus. Antiviral Res, 64(3): 189-194 

　　[52] Wang Q, Wang YT, Pu SP, Zheng YT*. (2004)Zinc coupling potentiate anti-HIV-1 activity of baicalin. Biochem Biophys Res Commun, 324:605-610. 

　　[53] Wang JH, Tam SC, Huang H, Ouyang DY, Wang YY, Zheng YT. (2004) Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro. Biochem Biophys Res Commun, 317(4):965-971 

　　[54] Zhang YJ, Wang JH, Li WH, Wang Q, Liu H, Zheng YT*, Zhang Y*. (2003) Molecular characterization of Trimeresurus stejnegeri venom L-amino acid oxidase with potential anti-HIV activity Biochem Biophys Res Commun, 309:598-604. 

　　[55] Wang JH, Nie HL, Huang H, Tam SC, Zheng YT*. (2003) Independency of anti-HIV-1 activity from ribosome inactivating activity of trichosanthin. Biochem Biophys Res Commun, 302(1):89-94  

　　[56] Wang JH, Nie HL, Tam SC, Huang H, Zheng YT*. (2002) Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity. FEBS Lett, 531(2):295-298  

　　[57] Zheng YT, Chan WL, Chan P, Huang H, Tam SC. (2001) Enhancement of the anti-herpetic effects of trichosanthin by acyclovir and interferon. FEBS Lett, 496(2-3):139-142 

　　Publications as co-author (Selected from 121 papers) 

　　[1] Liu R, Huang L, Li JY, Zhou XZ, Zhang HY, Zhang T, Lei YL, Wang K, Xie N, Zheng YT, Wang FS, Nice EC, Rong LJ, Huang CH, Wei YQ. (2013) HIV infection in gastric epithelial cells. J Infect Dis, 208(8):1221-30. 

　　[2] Fan Y, Huang ZY, Cao CC, Chen CS, Chen YX, Fan DD, He J, Hou HL, Hu L, Hu XT, Jiang XT, Lai R, Lang YS, Liang B, Liao SG, Mu D, Ma YY, Niu YY, Sun XQ, Xia JQ, Xiao J, Xiong ZQ, Xu L, Yang L, Zhang Y, Zhao W, Zhao XD, Zheng YT, Zhou JM, Zhu YB, Zhang GJ, Wang J, Yao YG. (2013)  Genome of the Chinese tree shrew. Nat Commun, 4:1426. 

　　[3] Liang CQ, Shi YM, Luo RH, Li XY, Gao ZH, Li XN, Yang LM, Shang SZ, Li Y, Zheng YT, Zhang HB, Xiao WL, Sun HD. (2012) Kadcoccitones A and B, two new 6/6/5/5-fused tetracyclic triterpenoids from Kadsura coccinea. Org Lett. 14(24):6362-6365. 

　　[4] Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Beamati N, Long YQ. (2012) Repositioning HIV？1 integrase inhibitors for cancer therapeutics: 1, 6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties. J Med Chem, 55(22):9492-9509. 

　　[5] Ma XD, He QQ, Zhang X, Yang SQ, Yang LM, Gu SX, Zheng YT, Chen FE, Dai HF. (2012) Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors. Eur J Med Chem. 58C:504-512. 

　　[6] Liu J, Jia YH, Xu Q, Zheng YT, Zhang C. (2012) Phylodynamics of HIV-1 unique recombinant forms in China-Myanmar border: implication for HIV-1 transmission to Myanmar from Dehong, China. Infect Genet Evol, 12:1944-1948.  

　　[7] Liu YY, Liu HL, He YQ, Li SL, Zheng YT, Wang HY, Gong XH. (2012) The genetic variation and association study of CCR5, CXCR4 and SDF-1 in different Chinese ethnic populations. Infect Genet Evol, 12(5):1072-1078.  

　　[8] Luo X, Shi YM, Luo RH, Luo SH, Li XN, Wang RR, Li SH, Zheng YT, Du X, Xiao WL, Pu JX, Sun HD. (2012) Schilancitrilactones A-C: three unique nortriterpenoids from Schisandra lancifolia. Org Lett. 14(5):1286-1289.  

　　[9] Kuang YQ, Pang W, Zheng YT, Dupre DJ. (2012) NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. Eur J Immunol, 42(2):299-310 

　　[10] Zhu YP, Chen GF, Lv FX, Wang XL, Ji X, Xu YH, Sun J, Wu L, Zheng YT, Gao GX. (2011) Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply-spliced viral mRNAs for degradation. Proc Natl Acad Sci USA, 108(38):15834-9. 

　　[11] Beall CM, Cavalleri GL, Deng LB, Elston RC, Gao Y, Knight J, Li CH, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah K, Wang W, Wangdui P, Weale ME, Xu YM, Xu Z, Yang L, Zaman MJ, Zeng CQ, Zhang L, Zhang XL, Zhaxi P, Zheng YT. (2010) Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA, 107(25):11459-11464 

　　[12] Zhang L, Luo RH, Wang F, Jiang MY, Dong ZJ, Yang LM, Zheng YT, Liu JK. (2010) High functionallized daphnane diterppenoids from Trigonostemon thyrsoideum. Org Lett, 12(1):152-155.  

　　[13] He J, Chen XQ, Li MM, Zhao Y, Xu G, Cheng X, Peng LY, Xie MJ, Zheng YT, Wang YP, Zhao QS. (2009) Lycojapodine A, a novel alkaloid from Lycopodium japonicum. Org Lett, 11(6):1397-400 

　　[14] Xiao WL, Lei C, Ren J, Liao TG, Pu JX, Pittman CU Jr, Lu Y, Zheng YT, Zhu HJ, Sun HD. (2008) Structure elucidation and theoretical investigation of key steps in the biogenetic pathway of schisanartane nortriterpenoids by using DFT methods. Chemistry, 14(36):11584-11592 

　　[15] Du L, Zhao YX, Chen J, Yang LM, Zheng YT, Tang Y, Shen X, Jiang HL. (2008) D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem Biophys Res Commun, 375(1):139-44.  

　　[16] Liu JF, Jiang ZY, Wang RR, Zheng YT, Chen JJ, Zhang XM, Ma YB. (2007) Isatisine A, a novel alkaloid with an unprecedented skeleton from leaves of Isatis indigotica. Org Lett, 9(21):4127-4129 

　　[17] Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng YT, Rees HH, Lai R, Yang D, Wu J. (2007) Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics, 6(5):882-894. 

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　　[19] Xu G, Hou AJ, Wang RR, Liang GY, Zheng YT, Liu ZY, Li XL, Zhao Y, Huang SX, Peng LY, Zhao QS. (2006) Przewalskin A: a new C (23) terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii Maxim. Org Lett, 8(20):4453-4456. 

　　[20] Li XL, Cheng X, Yang LM, Wang RR, Zheng YT, Xiao WL, Zhao Y, Xu G, Lu Y, Chang Y, Zheng QT, Zhao QS, Sun HD. (2006) Dichotomains A and B: two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma. Org Lett, 8(9):1937-1940 

　　[21] Xiao WL, Pu JX, Chang Y，Li XL, Huang SX, Yang LM,  Li LM, Lu Y, Zheng YT, Li RT, Zheng QT, Sun HD. (2006) Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera. Org Lett, 8(7):1475-1478 

　　[22] Xiao WL, Yang LM, Gong NB, Wu L, Wang RR, Pu JX, Li XL, Huang SX, Zheng YT, Li RT,  Lu Y, Zheng QT, Sun HD. (2006) Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities. Org Lett, 8(5):991-994 

　　[23] Xiao WL, Li RT, Li SH, Li XL, Sun HD, Zheng YT, Wang RR, Lu Y, Wang C, Zheng QT. (2005) Lancifodilactone F: a novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity. Org Lett, 7(7):1263-1266  

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　　[25] Li RT, Han QB, Zheng YT, Wang RR, Yang LM, Lu Y, Sang SQ, Zheng QT, Zhao QS , Sun HD. (2005) Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha. Chem Commun, 23:2936-2938. 

　　Lab Staff: 

　　Ms. Liu-Meng Yang, Associate Professor, lmyang@mail.kiz.ac.cn 

　　Dr. Wei Pang, Associate Professor, pangw@mail.kiz.ac.cn 

　　Dr. Gao-Hong Zhang, Assistant Professor, zhanggh@mail.kiz.ac.cn 

　　Rong-Hua Luo, Research Assistant, luoronghua@163.com   

　　Graduate Students: 

　　Hong-Yi Zheng, Ren-Rong Tian, Dan Mu, Jia-Wu Zhu, Lin Zhu, Xi-He  Zhang, Xin Chen, Huan Chen, Ming-Xu  Zhang, Xiao-Liang Zhang, Lin-Tao Zhang, Meng-Ting Luo, Ping Wang, Mei Ye, Jin Jiang, Xiao-Dong Lian, Xiang Yang, Min Chen, Si-Si Zhang, Chun-Tao Zhang, Si-Ying Xiang, Yan-Lin Ma.