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Details of the Faculty or Staff
Jing-Fei Huang
Vice Director of the Kunming Institute of Zoology
Highest Education 
Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
   +86 871 5195183
Zip Code  
   +86 871 5195183
Research Interest:

Professor Jing-Fei Huang is the director of structural bioinformatics lab which focused on the relationship between protein sequence, structure and function. We apply Discovery Studio on drug design, virtual screening, and the specific binding type between protein-small molecule, protein-nucleic acid. We explore the evolution history of immune related gene and gene family through comparative genomics. We develop several method to research the relationship between protein structure variance and function diversity. We use system biology method to find candidate drug target in complex disease.

Public Services:

Supported Projects:

National Basic Research (973) Program of China, National Innovation Group Program of China, National Natural Science Foundation of China, Knowledge Innovation Program of the Chinese Academy of Sciences

Selected Publication:
  1. Li GH, Huang JF. Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer. Bioinformatics, 2014. 30: 748?52.  
  2. Cheng DQ, Li Y, Huang JF. Molecular evolution of the primate a-/?-defensin multigene family. PLoS ONE, 2014. 9: e97425. doi: 10.1371/journal.pone.0097425.  
  3. Chen SM, Gao S, Cheng DQ, Huang JF. The characterization and comparison of amyloidogenic segments and non-amyloidogenic segments shed light on amyloid formation. Biochem Biophys Res Com, 2014. 447: 255?62.  
  4. Zhang AD, Dai SX, Huang JF. Reconstruction and analysis of human kidney-specific metabolic network based on omics data. BioMed Research International, 2013. 2013: doi:10.1155/2013/187509.  
  5. Yu Q, Huang JF. The DEER database: A bridge connecting drugs, environmental effects, and regulations. Gene, 2013. 520(2):98-105.  
  6. Wang J, Zhao YQ, Wang Y, Huang JF. Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex. FEBS Lett, 2013. 587(2):136-141.  
  7. Wu M, Yu Q, Li X, Zheng J, Huang JF, Kwoh CK. Benchmarking human protein complexes to investigate drug-related systems and evaluate predicted protein complexes. PLoS ONE, 2013. 8(2): e53197.  
  8. Xin YN, Zhao YQ, Lin ZH, Jiang X, Xuan SY, Huang JF. Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity. Proteins, 2013. 81(3): 406-414.  
  9. Li GH, Huang JF. CDRUG: a web server for predicting anticancer activity of chemical compounds. Bioinformatics, 2012. 28(24): 3334-3335.  
  10. Zhao YQ, Wang JW, Wang YJ, Huang JF. A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouse. J Clin Bioinformat, 2012. 2(1): 10.  
  11. Zhang YR, Zhao YQ, Huang JF. Retinoid-binding proteins: Similar protein architectures bind similar ligands via completely different ways. PLoS ONE, 2012. 7(5): e36772. 
  12. Yu Q, Huang JF. The analysis of the druggable families based on topological features in the protein-protein interaction network. Lett Drug Design Discovery, 2012. 9: 426-430.  
  13. Dai SX, Zhang AD, Huang JF. Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis. BMC Evol Biol, 2012. 12: 4.  
  14. Zhao YQ, Sheng ZZ, Huang JF. A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans. Mol. BioSyst, 2012. 8(2):504-10.  
  15. Zhao YQ, Huang JF. Reconstruction and analysis of human heart-specific metabolic network based on transcriptome and proteome data. Biochem Biophys Res Com, 2011. 415(3):450-4. 
  16. Sheng ZZ, Zhao YQ , Huang JF. Functional Evolution of BRCT Domains from Binding DNA to Protein. Evol Bioinformt, 2011. 7: 87?7.  
  17. Li, G-H, Huang JF. CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site annotation. BMC Bioinformt, 2010. 11: 439-451.  
  18. Tang SN, Huang JF. Evolution of different oligomeric glycyl-tRNA synthetases. FEBS Lett, 2005. 579: 1441-1445.  
  19. Huang JF. Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames. Mol Biol Evol, 2003. 20: 815-820.  
  20. Huang JF, Liu CQ. Identification of protein superfamily from structure-based sequence motif. Chinese Sci Bull, 2002. 47: 1377-1381.  
  21. Sowdhamini R, Burke DF, Deane CM, Huang JF. Mizuguchi K, Nagaaraajaram HA, Srinivasan N, Steward RE, Blundell TL. Protein 3D structural databases: Domains, structurally aligned homologues and superfamilies. Acta Crystall D, 1998. 54: 1168-1177. 
  22. Sowdhamini R, Burke DF, Huang JF, Mizuguchi K, Nagaaraajaram HA, Srinivasan N, Steward RE, Blundell TL. CAMPASS: A database of structural aligned protein superfamilies. Structure, 1998. 6: 1087-1094.  

Lab staff


Adress:No.32 Jiaochang Donglu Kunming 650223 Yunnan, China Tel:86-871-5199125