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Details of the Faculty or Staff
Name  
 Jian-Fan Wen
Title  
 Vice-director of the State Key Lab
Highest Education 
 Professor
Address  
 Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.Chian
Phone  
    +86 871 5198682
Zip Code  
    650223
Fax  
    +86 871 5198682
E-mail  
    wenjf@mail.kiz.ac.cn
 
Research Interest：
Dr, Wen’s Research interest is about the origin and evolution of the eukaryotic cell. At cellular and molecular levels, to investigate the biodiversity of cellular structures, functions, genes and genomes in eukaryotes of different evolutionary pos itions, and study the evolution of these aspects of eukaryotic cells.

Public Services：

Supported Projects：
Research in the Wen Lab focuses broadly on the evolution of eukaryotic cells. At cellular and molecular levels, we investigate the biodiversity of cellular structures, functions, genes and genomes in eukaryotes of different evolutionary positions, and study the evolution of these aspects of eukaryotic cells. Unicellular eukaryotes, protists, such as Giardia, Euglena, Chlamydomonas, and Choanoflagellates, which occupy key positions in the evolution of eukaryotic cells, are our preference materials. Combining with data of the ‘upstream’ organisms, prokaryotes, and the ‘downstream’ organisms, multicelluar eukaryotes, currently, we are focusing on the following aspect of the evolution of eukaryotic cells:
1) The biodiversity and evolution of some important eukaryotic cellular structures, including nuclear matrix and lamina, chromatin, and nucleolus;
2) The biodiversity and evolution of some important eukaryotic cellular functions and mechanisms, including nuclear division, cellular protein targeting, glycolysis, Calvin cycle, and biosynthesis of phospholipid;
3) The biodiversity and evolution of genes, gene families, functional pathway gene groups, and sub-genomes (e.g. nucleolar genome) of the above structures and functions.
4)  The adaptive evolution of some pests or pathogens (e.g. Giardia, Trichomonas, schistosome, and bloom cynobacteria) at genome level, and specific effective molecular targets for the control and treatment of this organisms.
The Wen Lab is a part of the State Key Laboratory of Genetic Resources and Evolution.

Selected Publication：

　　1. Feng JM, Tian HF, Wen JF*. Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus. 2013. Genome Biol Evol, 5(12):2255-67.  

　　2. Zhang YJ, Yang CL, Hao YJ, Li Y, Chen B*, Wen JF*. Macroevolutionary trends of atomic composition and related functional group proportion in eukaryotic and prokaryotic proteins. 2013. Gene, S0378-1119(13)01510-2 .  

　　3. Xiong J, Lu YM, Feng JM, ..., Miao W*. Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics. DATABASE-OXFORD. 2013. doi: 10.1093/database/bat008.   

　　4. Xu J, Cheng YQ, Chen B, …, Wen JF, …. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. 2013. Lupus. 22(10):1001-10.   

　　5. Gao S, Xiong J, …, Wen JF, …, Miao W, and Liu YF. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. 2013. Genes Dev. 27(15):1662-79.  

　　6. Sun GL, Yang YF, Xie FL, Wen JF, …. Deep Sequencing Reveals Transcriptome Re-Programming of Taxus × media Cells to the Elicitation with Methyl Jasmonate. 2013. PLoS ONE, 8(4):e62865.  

　　7、Jiang YH, Wang DY, Wen JF*.  The independent prokaryotic origins of eukaryotic fructose-1 6-bisphosphatase and sedoheptulose-1 7-bisphosphatase and the implications of their origins for the evolution of eukaryotic Calvin cycle. 2012. BMC Evol. Biol. 12:208  

　　8、Ni T, Yue JP, Sun GL, Zou Y, Wen JF*, Hang JL*.  Ancient gene transfer from algae to animals: Mechanisms and evolutionary significance. 2012 BMC Evol. Biol..12:83  

　　9、Feng JM, Sun J, Xin DD, Wen JF*, Comparative Analysis of the 5S rRNA and Its Associated Proteins Reveals Unique Primitive Rather Than Parasitic Feature in Graidia lamblia. 2012.  PLoS ONE. 7(6):e36978  

　　10、Tian HF, Feng JM, Wen JF*,  The evolution of cardiolipin biosynthesis and maturation pathways and its implications to the evolution for eukaryotes. 2012 BMC Evol. Biol..12:32  

　　11、Lin XD, Guo WP, Wang W, Zou Y, Hao ZY, Zhou DJ, Dong X, Qu YG, Li MH,. Tian HF, Wen JF, Alexander Plyusnin, Xu JG, Zhang YZ*.  Migration of Norway Rats Resulted in the Worldwide Distribution of Seoul Hantavirus Today. 2012. J VIROL. 86(2):972  

　　12、Chen B,Wen JF *,  The adaptive evolution divergence of triosephosphate isomerases between parasitic and free-living flatworms and the discovery of a potential universal target against flatworm parasites. 2011 Parasitol. Res., 109(2):283-9  

　　13、Sun J, Jiang HF, Flores R., Wen JF.*, Gene duplication in the genome of parasitic Giardia lamblia. 2010 BMC Evol. Biol..10:49  

　　14、Zhang YJ, Tian HF, Wen JF.* The evolution of YidC/Oxa/Alb3 family in the three domains of life: a phylogenomic analysis. 2009 BMC Evol. Biol.. 9:137  

　　15、Zhang YQ, Chen DL, Tian HF, Zhang BH, Wen JF*  Genome-wide computational identification of microRNAs and their targets in the deep-branching eukaryote Giardia lamblia. 2009 Comput Biol Chem..33(5):391-6.  

　　16、Sun GL., Shen W. and Wen JF.*, Triosephosphate isomerase (TIM) genes in two trophic modes of euglenoids (Euglenophyceae) and their phylogenetic analysis. 2008. J. Eukaryot. Microbiol. 55 (3): 170-177.  

　　17.Feng JM, Sun J, Wen JF.* Advances in the study of the nucleolus. 2012. Zoological Research. 33(6):549-556  

　　18. Zhang YJ, Wen JF.* YidC/Oxa/Alb3 Protein family. 2012. Chemistry of Life，32(4)  

　　19. Xie GQ, Chen B, Wen JF.* Research Progress on the Mechanisms of Immune Evasion of Parasitic Flatworms such as Schistosoma. 2013. Acta Parasitol. Med.Entomol.Sin 22(3):194-201.    
 
 

Lab staff


 

Adress：No.32 Jiaochang Donglu Kunming 650223 Yunnan, China Tel：86-871-5199125