CircGRIA1 Shows an Age-related Increase in Male Macaque Brain and Regulates Synaptic Plasticity and Synaptogenesis

author:	Xu K, Zhang Y, Xiong W, Zhang Z, Wang Z, Lv L, Liu C, Hu Z, Zheng YT, Lu L, Hu XT, Li J
Abstract:	Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA isoform derived from the genomic loci of α-mino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit Gria1, shows an age-related and male-specific increase in expression in the rhesus macaque prefrontal cortex and hippocampus. We show circGRIA1 is predominantly localized to the nucleus, and find an age-related increase in its association with the promoter region of Gria1 gene, suggesting it has a regulatory role in Gria1 transcription. In vitro and in vivo manipulation of circGRIA1 negatively regulates Gria1 mRNA and protein levels. Knockdown of circGRIA1 results in an age-related improvement of synaptogenesis, and GluR1 activity-dependent synaptic plasticity in the hippocampal neurons in males. Our findings underscore the importance of circRNA regulation and offer an insight into the biology of brain aging
Contact the author:
Page number:
Issue:
Subject:
Authors units:
PubYear:	2020
Volume:
Unit code:	152453
Publication name:	Nature Communications
The full text link:	Download
Full papers:	Download
Departmens of first author:
Paper source:	https://www.nature.com/articles/s41467-020-17435-7
Paper type:
Participation of the author:
EMAIL: