From Asymmetrical to Balanced Genomic Diversification during Rediploidization: Subgenomic Evolution in Allotetraploid Fish

author:	Jing Luo, Jing Chai, Yanling Wen, MinTao,Guoliang Lin, Xiaochuan Liu, Li Ren,Zeyu Chen, Shigang Wu , Shengnan Li, Yude Wang, Qinbo Qin, Shi Wang , Yun Gao,Feng Huang, Lu Wang, Cheng Ai, Xiaobo Wang, Lianwei L, Chengxi Ye, Huimin Yang,Mi Luo , Jie Chen, Hong Hu, Liujiao Yuan, Li Zhong, Jing Wang, Jian Xu, Zhenglin Du,Zhanshan (Sam) Ma , Robert W. Murphy, Axel Meyer, Jianfang Gui, Peng Xu,Jue Ruan, Z. Jeffrey Chen, Shaojun Liu, Xuemei Lu, Ya-ping Zhang
Abstract:	A persistent enigma is the rarity of polyploidy in animals, compared to its prevalence in plants. Although animal polyploids are thought to experience deleterious genomic chaos during initial polyploidization and subsequent rediploidization processes, this hypothesis has not been tested. We provide an improved reference-quality de novo genome for allotetraploid goldfish whose origin dates to ~15 million years ago. Comprehensive analyses identify changes in subgenomic evolution from asymmetrical oscillation in goldfish and common carp to diverse stabilization and balanced gene expression during continuous rediploidization. The homoeologs are coexpressed in most pathways, and their expression dominance shifts temporally during embryogenesis. Homoeolog expression correlates negatively with alternation of DNA methylation. The results show that allotetraploid cyprinids have a unique strategy for balancing subgenomic stabilization and diversification. Rediploidization process in these fishes provides intriguing insights into genome evolution and function in allopolyploid vertebrates
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PubYear:	2020
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Unit code:	152453
Publication name:	Science Advances
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Paper source:	https://advances.sciencemag.org/content/6/22/eaaz7677
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