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Salpratlactones A and B: A Pair of cis- trans Tautomeric Abietanes as Cav3.1 T-Type Calcium Channel Agonists from Salvia Prattii
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Xia F, Li WY, Yang XW, Yang J, Li X, Nian Y, Xu G |
| Abstract: |
Salpratlactones A (1) and B (2), a pair of abietane cis- trans tautomers from Salvia prattii, were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, 1 and 2 were featured by unique 6/5 carbocyclic rings bearing a γ-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 μM potently and equally increased Cav3.1 TTCC peak currents, and 1 had an EC50 value of 12.48 μM
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2019 |
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152453 |
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Organic Letters |
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| Paper source: |
https://pubs.acs.org/doi/10.1021/acs.orglett.9b01527 |
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