Home | Contact | Sitemap | 中文 | CAS
  About Research Education Partnerships People Resources  
Location:Location: Home>>Papers
CAS Members
Principal Investigator
Platelets Mediate Protective Neuroinflammation and Promote Neuronal Plasticity at the Site of Neuronal Injury
author: Dukhinova M, Kuznetsova I, Kopeykina E, Veniaminova E, Yung AWY, Veremeyko T, Levchuk K, Barteneva NS, Ho KKW, Yung WH, Liu JYH, Rudd J, Yau SSY, Anthony DC, Strekalova T, Ponomarev ED

It is generally accepted that inflammation within the CNS contributes to neurodegeneration after traumatic brain injury (TBI), but it is not clear how inflammation is initiated in the absence of infection and whether this neuroinflammation is predominantly beneficial or detrimental. We have previously found that brain-enriched glycosphingolipids within neuronal lipid rafts (NLR) induced platelet degranulation and secretion of neurotransmitters and pro-inflammatory factors. In the present study, we compared TBI-induced inflammation and neurodegeneration in wild-type vs. St3gal5 deficient (ST3-/-) mice that lack major CNS-specific glycosphingolipids. After TBI, microglial activation and CNS macrophage infiltration were substantially reduced in ST3-/- animals. However, ST3-/- mice had a larger area of CNS damage with marked neuronal/axonal loss. The interaction of platelets with NLR stimulated neurite growth, increased the number of PSD95-positive dendritic spines, and intensified neuronal activity. Adoptive transfer and blocking experiments provide further that platelet-derived serotonin and platelet activating factor plays a key role in the regulation of sterile neuroinflammation, hemorrhage and neuronal plasticity after TBI

Contact the author:
Page number:
Authors units:
PubYear: 2018
Unit code: 152453
Publication name: Brain Behavior and Immunity
The full text link: Download
Full papers: Download
Departmens of first author:
Paper source:
Paper type:
Participation of the author:
  Home Mail Login Intranet login Living and Working in Kunming
Copyright© Kunming Institute of Zoology Chinese Academy of Sciences .All Rights Reserved
Address:No.32 Jiaochang Donglu Kunming 650223 Yunnan,China
Tel:+86 871 65130513 Fax:+86 871 65191823 【mail】