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TET3-mediated DNA Oxidation Promotes ATR-dependent DNA Damage Response
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author: |
Jiang D, Wei S, Chen F, Zhang Y, Li J |
Abstract: |
An efficient, accurate, and timely DNA damage response (DDR) is crucial for the maintenance of genome integrity. Here, we report that ten-eleven translocation dioxygenase (TET) 3-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in response to ATR-dependent DDR regulates DNA repair. ATR-dependent DDR leads to dynamic changes in 5hmC levels and TET3 enzymatic activity. We show that TET3 is an ATR kinase target that oxidizes DNA during ATR-dependent DNA damage repair. Modulation of TET3 expression and activity affects DNA damage signaling and DNA repair and consequently cell death. Our results provide novel insight into ATR-mediated DDR, in which TET3-mediated DNA demethylation is crucial for efficient DNA repair and maintenance of genome stability
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2018 |
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152453 |
Publication name: |
EMBO Reports |
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Paper source: |
http://embor.embopress.org/content/18/5/781.long |
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